Flow-mediated outward arterial remodeling in aging
Sign Up to like & getrecommendations! Published in 2021 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2020.111416
Abstract: The present review focuses on the effect of aging on flow-mediated outward remodeling (FMR) via alterations in estrogen metabolism, oxidative stress and inflammation. In ischemic disorders, the ability of the vasculature to adapt or remodel… read more here.
Keywords: outward arterial; aging flow; arterial remodeling; flow mediated ... See more keywords
MEKK3-TGFβ crosstalk regulates inward arterial remodeling.
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112625118
Abstract: Arterial remodeling is an important adaptive mechanism that maintains normal fluid shear stress in a variety of physiologic and pathologic conditions. Inward remodeling, a process that leads to reduction in arterial diameter, plays a critical… read more here.
Keywords: inward remodeling; tgf; arterial remodeling; inward arterial ... See more keywords
Nesfatin-1 suppresses peripheral arterial remodeling without elevating blood pressure in mice
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine Connections"
DOI: 10.1530/ec-19-0120
Abstract: Nesfatin-1 is a novel anorexic peptide hormone that also exerts cardiovascular protective effects in rodent models. However, nesfatin-1 treatment at high doses also exerts vasopressor effects, which potentially limits its therapeutic application. Here, we evaluated… read more here.
Keywords: blood pressure; treatment; mice; arterial remodeling ... See more keywords
Thrombospondins differentially regulate proteins involved in arterial remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Physiological research"
DOI: 10.33549/physiolres.934148
Abstract: Thrombospondins (TSPs) are matricellular glycoproteins expressed in response to vascular injury. TSP-1 and TSP-2 are promotors of arterial remodeling while TSP-5 is believed to be protective. The current study assessed the differential effect of TSPs… read more here.
Keywords: expression; involved arterial; arterial remodeling; tsp tsp ... See more keywords
Role of Brain Arterial Remodeling in HIV-Associated Cerebrovascular Outcomes
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DOI: 10.3389/fneur.2021.593605
Abstract: As the life expectancy of people living with HIV (PLWH) on combination antiretroviral therapy (cART) increases, so does morbidity from cerebrovascular disease and neurocognitive disorders. Brain arterial remodeling stands out as a novel investigational target… read more here.
Keywords: cart; brain arterial; hiv; arterial remodeling ... See more keywords
Cathepsin S Inhibition Suppresses Experimental Systemic Lupus Erythematosus-Associated Pulmonary Arterial Remodeling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012316
Abstract: Patients with systemic lupus erythematosus (SLE) associated with pulmonary arterial hypnertension (PAH) receive targeted therapy for PAH to decrease pulmonary arterial systolic pressure and significantly prolong their survival. Cysteine cathepsin proteases play critical roles in… read more here.
Keywords: sle; pulmonary arterial; sle pah; arterial remodeling ... See more keywords