Mechanical programming of arterial smooth muscle cells in health and ageing
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DOI: 10.1007/s12551-021-00833-6
Abstract: Arterial smooth muscle cells (ASMCs), the predominant cell type within the arterial wall, detect and respond to external mechanical forces. These forces can be derived from blood flow (i.e. pressure and stretch) or from the… read more here.
Keywords: arterial smooth; arterial wall; muscle cells; smooth muscle ... See more keywords
hsa_circWDR37_016 Regulates Hypoxia-Induced Proliferation of Pulmonary Arterial Smooth Muscle Cells
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DOI: 10.1155/2022/7292034
Abstract: Pulmonary arterial hypertension (PAH) is characterized by abnormal remodeling of pulmonary vessel walls caused by excessive pulmonary arterial smooth muscle cell (PASMC) proliferation. Our previous clinical studies have demonstrated the importance of the downregulated circRNA… read more here.
Keywords: proliferation; pulmonary arterial; hsa circwdr37; arterial smooth ... See more keywords
LncPTSR Triggers Vascular Remodeling in Pulmonary Hypertension by Regulating [Ca2+]i in Pulmonary Arterial Smooth Muscle Cells.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2020-0480oc
Abstract: Pulmonary hypertension (PH) is characterized by vascular remodeling and sustained increase in right ventricular systolic pressure (RVSP). The molecular mechanisms behind PH development remain unclear. Here, a long non-coding RNA (lncRNA) attenuated by platelet-derived growth… read more here.
Keywords: arterial smooth; muscle cells; pulmonary arterial; smooth muscle ... See more keywords
Mechanism of anti-remodelling action of treprostinil in human pulmonary arterial smooth muscle cells
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DOI: 10.1371/journal.pone.0205195
Abstract: Treprostinil is applied for pulmonary arterial hypertension (PAH) therapy. However, the mechanism by which the drug achieves its beneficial effects in PAH vessels is not fully understood. This study investigated the effects of treprostinil on… read more here.
Keywords: arterial smooth; pulmonary arterial; muscle cells; smooth muscle ... See more keywords
5-HT promotes pulmonary arterial smooth muscle cell proliferation through the TRPC channel.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2018.64.13.17
Abstract: Pulmonary arterial hypertension is caused by an imbalance of pulmonary vasoconstriction and vasodilation. Pulmonary arteriolar remodeling is a primary pathological change and proliferation of pulmonary arterial smooth muscle cells (PASMC) is an important pathological basis… read more here.
Keywords: arterial smooth; proliferation; pulmonary arterial; smooth muscle ... See more keywords
Rho kinase and Na+/H+ exchanger mediate endothelin‐1‐induced pulmonary arterial smooth muscle cell proliferation and migration
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DOI: 10.14814/phy2.13698
Abstract: Excessive production of endothelin‐1 (ET‐1) has been observed in almost all forms of pulmonary hypertension. ET‐1, a highly potent vasoconstrictor, can also potentiate pulmonary arterial smooth muscle cell (PASMC) growth and migration, both of which… read more here.
Keywords: proliferation migration; arterial smooth; proliferation; pulmonary arterial ... See more keywords
NF-κB/p65 Competes With Peroxisome Proliferator-Activated Receptor Gamma for Transient Receptor Potential Channel 6 in Hypoxia-Induced Human Pulmonary Arterial Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.656625
Abstract: Objective: Peroxisome proliferator-activated receptor gamma (PPARγ) has an anti-proliferation effect on pulmonary arterial smooth muscle cells (PASMCs) via the transient receptor potential channel (TRPC) and protects against pulmonary artery hypertension (PAH), whereas nuclear factor-kappa B… read more here.
Keywords: ppar; p65; arterial smooth; pulmonary arterial ... See more keywords
Chemerin Regulates the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via the ERK1/2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.767705
Abstract: Pulmonary arterial hypertension (PAH) is an incurable disease with high mortality. Chemerin has been found to be associated with pulmonary hypertension (PH). However, the specific role of chemerin in mediating PH development remains unclear. This… read more here.
Keywords: erk1; chemerin; pulmonary arterial; migration ... See more keywords