Loss of c‐Kit function impairs arteriogenesis in a mouse model of hindlimb ischemia
Sign Up to like & getrecommendations! Published in 2018 at "Surgery"
DOI: 10.1016/j.surg.2017.10.052
Abstract: Background. Arteriogenesis is a process whereby collateral vessels remodel usually in response to increased blood flow and/or wall stress. Remodeling of collaterals can function as a natural bypass to alleviate ischemia during arterial occlusion. Here… read more here.
Keywords: recovery; hindlimb ischemia; arteriogenesis; kit ... See more keywords
Role of endothelial Raptor in abnormal arteriogenesis after lower limb ischemia in type-2 diabetes.
Sign Up to like & getrecommendations! Published in 2024 at "Cardiovascular research"
DOI: 10.1093/cvr/cvae105
Abstract: AIMS Proper arteriogenesis after tissue ischemia is necessary to rebuild stable blood circulation; nevertheless, this process is impaired in type-2 diabetes mellitus (T2DM). Raptor, is a scaffold protein and a component of mammalian target of… read more here.
Keywords: arteriogenesis; ischemia; role endothelial; endothelial raptor ... See more keywords
Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.315478
Abstract: Supplemental Digital Content is available in the text. Objective: The dominant driver of arteriogenesis is elevated shear stress sensed by the endothelial glycocalyx thereby promoting arterial outward remodeling. Hyaluronan, a critical component of the endothelial… read more here.
Keywords: has3; arteriogenesis; cd44; hyaluronan ... See more keywords
Ischemic-Trained Monocytes Improve Arteriogenesis in a Mouse Model of Hindlimb Ischemia
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.317197
Abstract: Supplemental Digital Content is available in the text. Objective: Monocytes, which play an important role in arteriogenesis, can build immunologic memory by a functional reprogramming that modifies their response to a second challenge. This process,… read more here.
Keywords: arteriogenesis; trained monocytes; ischemic trained; hindlimb ischemia ... See more keywords
Notch Signaling-Modified Mesenchymal Stem Cell Patch Improves Left Ventricular Function via Arteriogenesis Induction in a Rat Myocardial Infarction Model
Sign Up to like & getrecommendations! Published in 2023 at "Cell Transplantation"
DOI: 10.1177/09636897231154580
Abstract: For ischemic cardiomyopathy (ICM) with limited therapeutic options, the induction of arteriogenesis has the potential to improve cardiac function through major restoration of blood flow. We hypothesized that transplantation of a Notch signaling-modified mesenchymal stem… read more here.
Keywords: cell; function; arteriogenesis; cell patch ... See more keywords
Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05748-w
Abstract: Background Vasculogenic therapies explored for the treatment of peripheral artery disease (PAD) have encountered minimal success in clinical trials. Addressing this, B55α, an isoform of protein phosphatase 2A (PP2A), emerges as pivotal in vessel remodeling… read more here.
Keywords: etrinabdione; vce 004; b55; arteriogenesis ... See more keywords
The role of therapeutic MicroRNA in arteriogenesis process in limb ischemia: A systematic review
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DOI: 10.12688/f1000research.147482.1
Abstract: Background Chronic limb-threatening ischemia (CLTI) is the most advanced stage of peripheral artery disease (PAD) and has poor clinical outcomes. Recently, stimulating arteriogenesis has been proposed to improve clinical outcomes. Several studies have shown that… read more here.
Keywords: review; role; ischemia; arteriogenesis ... See more keywords
Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.761007
Abstract: Lower extremity arterial occlusive disease (AOD) results in significant morbidity and mortality for the population, with up to 10% of patients ultimately requiring amputation. An alternative method for non-surgical revascularization which is yet to be… read more here.
Keywords: extracellular matrix; matrix; arteriogenesis; remodeling extracellular ... See more keywords
P2Y12-Inhibitor Clopidogrel Promotes Collateral Artery Growth in a Murine Hindlimb Model of Arteriogenesis
Sign Up to like & getrecommendations! Published in 2025 at "Biomedicines"
DOI: 10.3390/biomedicines13112790
Abstract: Background/Objectives: Clopidogrel is a P2Y12 receptor inhibitor commonly used as antiplatelet therapy for patients with cardiovascular occlusive diseases. However, its role in vascular remodeling remains poorly understood. Platelets orchestrate the sterile inflammation in arteriogenesis, an… read more here.
Keywords: murine hindlimb; model arteriogenesis; hindlimb model; arteriogenesis ... See more keywords
The Extraordinary Role of Extracellular RNA in Arteriogenesis, the Growth of Collateral Arteries
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DOI: 10.3390/ijms20246177
Abstract: Arteriogenesis is an intricate process in which increased shear stress in pre-existing arteriolar collaterals induces blood vessel expansion, mediated via endothelial cell activation, leukocyte recruitment and subsequent endothelial and smooth muscle cell proliferation. Extracellular RNA… read more here.
Keywords: shear stress; arteriogenesis; extraordinary role; growth ... See more keywords
Cobra Venom Factor Boosts Arteriogenesis in Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158454
Abstract: Arteriogenesis, the growth of natural bypass blood vessels, can compensate for the loss of arteries caused by vascular occlusive diseases. Accordingly, it is a major goal to identify the drugs promoting this innate immune system-driven… read more here.
Keywords: factor boosts; venom factor; arteriogenesis; cobra venom ... See more keywords