Effect of artesunate and relation with TGF-β1 and SMAD3 signaling on experimental hypertrophic scar model in rabbit ear
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-019-01960-7
Abstract: Artesunate (ART) is the derivative of artemisinin isolated from the traditional Chinese medicine qinghao. Although several studies reported the efficiency of artesunate in the treatment of malaria, inhibiting fibroblasts and collagen synthesis, the association between… read more here.
Keywords: hypertrophic scar; rabbit ear; group; artesunate ... See more keywords
Delayed haemolysis after artesunate therapy in a cohort of patients with severe imported malaria due to Plasmodium falciparum.
Sign Up to like & getrecommendations! Published in 2017 at "Enfermedades infecciosas y microbiologia clinica"
DOI: 10.1016/j.eimc.2015.11.003
Abstract: INTRODUCTION Delayed haemolytic anaemia is one of the more frequent events after treatment with intravenous artesunate in patients with severe malaria. Little is known about its frequency and the outcomes of patients with this condition.… read more here.
Keywords: plasmodium falciparum; patients severe; artesunate; delayed haemolysis ... See more keywords
Widening the options for recurrent malaria
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DOI: 10.1016/s0140-6736(18)30630-5
Abstract: The global need for new antimalarial drugs and new combinations is enormous and urgent, but their successful delivery needs resilience to overcome the barriers imposed by expensive and lengthy clinical development plans. Attention is often… read more here.
Keywords: artesunate dihydroartemisinin; recurrent malaria; pyronaridine artesunate; artesunate ... See more keywords
Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma
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DOI: 10.1038/s41401-020-0478-3
Abstract: Sorafenib is the first-line medication for advanced hepatocellular carcinoma (HCC), but it can only extend limited survival. It is imperative to find a combination strategy to increase sorafenib efficacy. Artesunate is such a preferred candidate,… read more here.
Keywords: hepatocellular carcinoma; induce ferroptosis; treatment; sorafenib ... See more keywords
Assessment of quantitative and semi-quantitative biological test methods of artesunate in vitro.
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DOI: 10.1051/parasite/2022019
Abstract: Artesunate is the current most potent antimalarial drug widely used for the treatment of malaria. Considering the emergence of artemisinin resistance, several situations may require a simple method for artesunate quantification. We thus developed a… read more here.
Keywords: quantitative biological; artesunate; semi quantitative; quantitative semi ... See more keywords
An evaluation of rectal artesunate for the pre-hospital management of severe malaria
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2020.1718108
Abstract: ABSTRACT Introduction Severe falciparum malaria stills accounts for around half a million childhood deaths per year in sub-Saharan Africa. Prompt treatment of sick children close to home starting with artesunate given rectally by appropriately trained… read more here.
Keywords: artesunate pre; pre hospital; evaluation rectal; malaria ... See more keywords
The Anti-Malarial Drug Artesunate Attenuates Cardiac Injury in a Rodent Model of Myocardial Infarction.
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DOI: 10.1097/shk.0000000000000963
Abstract: Ischaemic heart disease remains the leading cause of morbidity and mortality in the Western world. Artesunate is the WHO-recommended drug of choice for complicated malaria (with organ failure). The administration of high doses of artesunate… read more here.
Keywords: anti malarial; drug; model; artesunate ... See more keywords
Measuring the Plasmodium falciparum HRP2 protein in blood from artesunate-treated malaria patients predicts post-artesunate delayed hemolysis
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaf9377
Abstract: Previously parasitized erythrocytes in patients with severe malaria retain the parasite protein HRP2, which can be used to predict hemolysis induced by the drug artesunate. A quick test to predict artesunate-induced anemia Anemia frequently affects… read more here.
Keywords: red blood; hrp2; artesunate treated; blood ... See more keywords
Abstract 5109: Beyond malaria: Second career of artesunate as cancer drug
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DOI: 10.1158/1538-7445.am2017-5109
Abstract: More than a decade ago, we initiated a research program on the molecular pharmacology of phytochemicals derived from Chinese medicinal herbs. Bioactive plant extracts have been fractionated by chromatographic techniques. We isolated bioactive compounds and… read more here.
Keywords: medicine; research; drug; artesunate ... See more keywords
Efficacy of Artesunate for Treatment of Cytomegalovirus Reactivations in Allogeneic Haematopoietic Stem Cell Transplant Recipients Who Are Intolerant/Unsuitable for Ganciclovir Therapy
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DOI: 10.1182/blood-2019-128766
Abstract: Background: Cytomegalovirus (CMV) reactivations are common post allogeneic stem cell transplant (ASCT) especially in developing countries like India, where most of the patients as well as donors are CMV seropositive. Ganciclovir is the drug of… read more here.
Keywords: cmv; line; stem cell; artesunate ... See more keywords
Assessment of Thermal and Hydrolytic Stabilities and Aqueous Solubility of Artesunate for Formulation Studies
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DOI: 10.1208/s12249-022-02490-8
Abstract: For the purpose of establishing the optimum processing parameters and storage conditions associated with nanolipid formulations of the artemisinin derivative artesunate, it was necessary to evaluate the thermal stability and solubility profiles of artesunate in… read more here.
Keywords: solubility; artesunate; solubility artesunate; thermal hydrolytic ... See more keywords