MEFAS, a hybrid of artesunate-mefloquine active against asexual stages of Plasmodium vivax in field isolates, inhibits malaria transmission
Sign Up to like & getrecommendations! Published in 2021 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2021.09.003
Abstract: Human malaria continues to be a public health problem and an important cause of morbidity and mortality in the world. Malaria control is achieved through both individual protection against mosquito bites and drug treatment, which… read more here.
Keywords: field isolates; transmission; artesunate mefloquine; malaria transmission ... See more keywords
Safety assessment of MEFAS: an innovative hybrid salt of mefloquine and artesunate for malaria treatment
Sign Up to like & getrecommendations! Published in 2019 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2019.1607371
Abstract: Abstract Malaria is a global public health problem that causes approximately 445 000 deaths annually worldwide, especially in underdeveloped countries. Because of the high prevalence and mortality of the disease, new and less toxic therapeutic… read more here.
Keywords: malaria; hybrid salt; safety; artesunate mefloquine ... See more keywords
Prediction of improved antimalarial chemotherapy of artesunate-mefloquine in combination with mefloquine sensitive and resistant Plasmodium falciparum malaria
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0282099
Abstract: Background Declining in susceptibility of Plasmodium falciparum to mefloquine is reported in South-East Asia. A revisiting on mefloquine pharmacokinetics-pharmacodynamics (PK/PD) could assist in finding new appropriate dosage regimens in combination with artesunate as a three-day… read more here.
Keywords: mefloquine sensitive; mefloquine; ic50; combination ... See more keywords