Methotrexate for psoriatic arthritis.
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DOI: 10.1002/14651858.cd012722
Abstract: BACKGROUND Psoriatic arthritis is an inflammatory disease associated with joint damage, impaired function, pain, and reduced quality of life. Methotrexate is a disease-modifying anti-rheumatic drug (DMARD) commonly prescribed to alleviate symptoms, attenuate disease activity, and… read more here.
Keywords: psoriatic arthritis; methotrexate; disease; adverse events ... See more keywords
Cationic Block Copolymer Nanoparticles with Tunable DNA Affinity for Treating Rheumatoid Arthritis
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DOI: 10.1002/adfm.202000391
Abstract: A high concentration of cell‐free DNA (cfDNA) in joints is considered a disease causative agent of rheumatoid arthritis (RA) and cfDNA scavenging has been regarded as an efficient therapeutic avenue. Cationic polymers can hamper progression… read more here.
Keywords: rheumatoid arthritis; arthritis; block copolymer; block ... See more keywords
Inflammation‐Instructed Hierarchical Delivery of IL‐4/miR‐21 Orchestrates Osteoimmune Microenvironment toward the Treatment of Rheumatoid Arthritis
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DOI: 10.1002/adfm.202101033
Abstract: Dysregulated inflammation and failure in resolution account for the incidence and deterioration of rheumatoid arthritis (RA). IL‐4 and miR‐21 possess complementary functions in inhibiting inflammation and fostering resolution. Thus, inflammation‐instructed nanocomplexes (NCs) are herein developed… read more here.
Keywords: arthritis; mir; delivery mir; microenvironment ... See more keywords
Significantly Improving the Bioefficacy for Rheumatoid Arthritis with Supramolecular Nanoformulations.
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DOI: 10.1002/adma.202100098
Abstract: As a typical inflammatory disease with chronic pain syndromes, rheumatoid arthritis (RA) generally requires long-term treatment with frequent injection administration at 1-2 times per day, because common medications such as interleukin1 receptor antagonist (IL1ra) have… read more here.
Keywords: bioefficacy rheumatoid; significantly improving; rheumatoid arthritis; arthritis ... See more keywords
Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis
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DOI: 10.1002/advs.202105188
Abstract: The aging of population has resulted in a significant increase in the prevalence of rheumatoid arthritis (RA), which is a persistent and recurrent synovial inflammation caused by abnormal immune activation. Herein, the authors designed an… read more here.
Keywords: arthritis; rheumatoid arthritis; inflammation triggered; local dynamic ... See more keywords
ECM‐Inspired Hydrogels with ADSCs Encapsulation for Rheumatoid Arthritis Treatment
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206253
Abstract: Due to their intrinsic anti‐inflammatory and immunomodulatory properties, adipose‐derived stem cells (ADSCs) are explored as a promising alternative in treating rheumatoid arthritis (RA). To address the poor survival and function loss of directly injected stem… read more here.
Keywords: hydrogel; ecm inspired; rheumatoid arthritis; arthritis ... See more keywords
Therapeutic management of arthritis: A review on structural and target‐based approaches
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DOI: 10.1002/ardp.202200182
Abstract: Inflammation is the natural defense mechanism against any external stimuli in the human body and it saves us from foreign entities that may alter our bodies' normal functioning. Any anomaly in this natural defense system… read more here.
Keywords: management arthritis; arthritis review; rheumatoid arthritis; arthritis ... See more keywords
CD11b regulates the Treg/Th17 balance in murine arthritis via IL‐6
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DOI: 10.1002/eji.201646565
Abstract: Th17 cells are often associated with autoimmunity and been shown to be increased in CD11b−/− mice. Here, we examined the role of CD11b in murine collagen‐induced arthritis (CIA). C57BL/6 and CD11b−/− resistant mice were immunized… read more here.
Keywords: cd11b mice; treg th17; cd11b; mice ... See more keywords
Combined Collagen‐Induced Arthritis and Organic Dust‐Induced Airway Inflammation to Model Inflammatory Lung Disease in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3745
Abstract: Rheumatoid arthritis (RA) is characterized by extra‐articular involvement including lung disease, yet the mechanisms linking the two conditions are poorly understood. The collagen‐induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway… read more here.
Keywords: cia ode; cia; ode; disease ... See more keywords
Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis
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DOI: 10.1002/jcb.29502
Abstract: Rheumatoid arthritis is a highly debilitating inflammatory autoimmune disease which is characterized by joint destruction. The present study sought to investigate the effect of quercetin in rats with complete Freund's adjuvant‐induced arthritis. Animals were divided… read more here.
Keywords: hepatoprotective genoprotective; genoprotective cytoprotective; effects quercetin; antioxidant hepatoprotective ... See more keywords
Regulatory and other rheumatoid factors in rheumatoid arthritis patients with active disease or in remission
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24187
Abstract: Previously, we identified a regulatory rheumatoid factor (regRF), the production of which provides rats with resistance to collagen‐induced arthritis (CIA). Immunization with conformers of IgG Fc fragments carrying epitopes specific to regRF reduces symptoms of… read more here.
Keywords: factors rheumatoid; rheumatoid arthritis; arthritis; rheumatoid factors ... See more keywords