Methotrexate for psoriatic arthritis.
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DOI: 10.1002/14651858.cd012722
Abstract: BACKGROUND Psoriatic arthritis is an inflammatory disease associated with joint damage, impaired function, pain, and reduced quality of life. Methotrexate is a disease-modifying anti-rheumatic drug (DMARD) commonly prescribed to alleviate symptoms, attenuate disease activity, and… read more here.
Keywords: psoriatic arthritis; methotrexate; disease; adverse events ... See more keywords
Cationic Block Copolymer Nanoparticles with Tunable DNA Affinity for Treating Rheumatoid Arthritis
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DOI: 10.1002/adfm.202000391
Abstract: A high concentration of cell‐free DNA (cfDNA) in joints is considered a disease causative agent of rheumatoid arthritis (RA) and cfDNA scavenging has been regarded as an efficient therapeutic avenue. Cationic polymers can hamper progression… read more here.
Keywords: rheumatoid arthritis; arthritis; block copolymer; block ... See more keywords
Inflammation‐Instructed Hierarchical Delivery of IL‐4/miR‐21 Orchestrates Osteoimmune Microenvironment toward the Treatment of Rheumatoid Arthritis
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DOI: 10.1002/adfm.202101033
Abstract: Dysregulated inflammation and failure in resolution account for the incidence and deterioration of rheumatoid arthritis (RA). IL‐4 and miR‐21 possess complementary functions in inhibiting inflammation and fostering resolution. Thus, inflammation‐instructed nanocomplexes (NCs) are herein developed… read more here.
Keywords: arthritis; mir; delivery mir; microenvironment ... See more keywords
A Multifunctional Enzyme Cascade Catalytic Nanoplatform for Effective Synergistic Therapy of Rheumatoid Arthritis
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DOI: 10.1002/adfm.202423054
Abstract: Insufficient oxygen supply and elevated levels of reactive oxygen species (ROS) in rheumatoid arthritis (RA) joints synergistically exacerbate inflammation and accelerate disease progression. In this study, a hybrid nanoassembly composed of superoxide dismutase (SOD) and… read more here.
Keywords: therapy; multifunctional enzyme; psc igu; rheumatoid arthritis ... See more keywords
Responsive Multi‐Arm PEG‐Modified COF Nanocomposites: Dynamic Photothermal, pH/ROS Dual‐Responsive, Targeted Carriers for Rheumatoid Arthritis Treatment
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DOI: 10.1002/adhm.202401744
Abstract: Rheumatoid arthritis (RA) is a chronic immune disease characterized by the infiltration of immune cells and the proliferation of fibroblast‐like synoviocytes (FLS) at the joint site, leading to inflammation and joint destruction. However, the available… read more here.
Keywords: treatment; multi; rheumatoid arthritis; arthritis ... See more keywords
Prodrug Nanomedicine for Synovium Targeted Therapy of Inflammatory Arthritis: Insights from Animal Model and Human Synovial Joint Fluid
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DOI: 10.1002/adhm.202401936
Abstract: Many patients cannot tolerate low‐dose weekly methotrexate (MTX) therapy for inflammatory arthritis treatment due to life‐threatening toxicity. Although biologics offer a target‐specific therapy, it raises the risk of serious infections and even cancer due to… read more here.
Keywords: therapy inflammatory; inflammatory arthritis; model; fluid ... See more keywords
Significantly Improving the Bioefficacy for Rheumatoid Arthritis with Supramolecular Nanoformulations.
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DOI: 10.1002/adma.202100098
Abstract: As a typical inflammatory disease with chronic pain syndromes, rheumatoid arthritis (RA) generally requires long-term treatment with frequent injection administration at 1-2 times per day, because common medications such as interleukin1 receptor antagonist (IL1ra) have… read more here.
Keywords: bioefficacy rheumatoid; significantly improving; rheumatoid arthritis; arthritis ... See more keywords
Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis
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DOI: 10.1002/advs.202105188
Abstract: The aging of population has resulted in a significant increase in the prevalence of rheumatoid arthritis (RA), which is a persistent and recurrent synovial inflammation caused by abnormal immune activation. Herein, the authors designed an… read more here.
Keywords: arthritis; rheumatoid arthritis; inflammation triggered; local dynamic ... See more keywords
ECM‐Inspired Hydrogels with ADSCs Encapsulation for Rheumatoid Arthritis Treatment
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DOI: 10.1002/advs.202206253
Abstract: Due to their intrinsic anti‐inflammatory and immunomodulatory properties, adipose‐derived stem cells (ADSCs) are explored as a promising alternative in treating rheumatoid arthritis (RA). To address the poor survival and function loss of directly injected stem… read more here.
Keywords: hydrogel; ecm inspired; rheumatoid arthritis; arthritis ... See more keywords
Metabolic Reprogramming of Macrophages by Biomimetic Melatonin‐Loaded Liposomes Effectively Attenuates Acute Gouty Arthritis in a Mouse Model
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DOI: 10.1002/advs.202410107
Abstract: Gouty arthritis is characterized by an acute inflammatory response triggered by monosodium urate (MSU) crystals deposited in the joints and periarticular tissues. Current treatments bring little effects owing to serious side effects, necessitating the exploration… read more here.
Keywords: gouty arthritis; loaded liposomes; melatonin loaded; arthritis ... See more keywords
Therapeutic management of arthritis: A review on structural and target‐based approaches
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200182
Abstract: Inflammation is the natural defense mechanism against any external stimuli in the human body and it saves us from foreign entities that may alter our bodies' normal functioning. Any anomaly in this natural defense system… read more here.
Keywords: management arthritis; arthritis review; rheumatoid arthritis; arthritis ... See more keywords