Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis
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DOI: 10.1038/s41598-017-15802-x
Abstract: Perturbations of the intestinal microbiome have been observed in patients with new-onset and chronic autoimmune inflammatory arthritis. However, it is currently unknown whether these alterations precede the development of arthritis or are rather a consequence… read more here.
Keywords: modulation; intestinal microbiome; intestinal microbiota; arthritis mice ... See more keywords
The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1
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DOI: 10.1186/s12967-017-1131-x
Abstract: BackgroundLeflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, the molecular mechanism of the… read more here.
Keywords: 1726 treated; a77 1726; heme oxygenase; arthritis mice ... See more keywords