Pathway-Specific Alterations of Cortico-Amygdala Transmission in an Arthritis Pain Model.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00022
Abstract: Medial prefrontal cortex (mPFC) and amygdala are closely interconnected brain areas that play a key role in cognitive-affective aspects of pain through their reciprocal interactions. Clinical and preclinical evidence suggests that dysfunctions in the mPFC-amygdala… read more here.
Keywords: transmission; pathway; arthritis pain; pain model ... See more keywords
Emodin alleviates arthritis pain through reducing spinal inflammation and oxidative stress
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DOI: 10.1177/17448069221146398
Abstract: Chronic pain is the predominant problem for rheumatoid arthritis patients, and negatively affects quality of life. Arthritis pain management remains largely inadequate, and developing new treatment strategies are urgently needed. Spinal inflammation and oxidative stress… read more here.
Keywords: pain; treatment; spinal inflammation; arthritis pain ... See more keywords
GSK-3β inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation
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DOI: 10.1371/journal.pone.0284332
Abstract: Pain is the main symptom of osteoarthritis, which severely reduces the patients’ quality of life. Stimulated neuroinflammation and elevated mitochondrial oxidative stress are associated arthritis pain. In the present study, arthritis model was established by… read more here.
Keywords: arthritis pain; alleviates arthritis; activity; pain ... See more keywords
Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis
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DOI: 10.3390/ph11040105
Abstract: Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid arthritis, and gout. This review summarizes the relevant data supporting a role… read more here.
Keywords: receptor potential; transient receptor; evidence transient; arthritis pain ... See more keywords