Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses.
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DOI: 10.1002/dta.2170
Abstract: The use of corticosteroids, such as betamethasone, in performance horses is tightly regulated. The objective of the current study was to describe the plasma pharmacokinetics of betamethasone as well as time-related urine and synovial fluid… read more here.
Keywords: urine synovial; betamethasone; articular administration; synovial fluid ... See more keywords
Closed suction drainage is not beneficial in hybrid total hip arthroplasty with intra-articular administration of tranexamic acid: a propensity score-matched cohort study
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DOI: 10.1007/s00264-022-05366-5
Abstract: This retrospective study aimed to evaluate the benefits of closed suction drainage (CSD) in hybrid total hip arthroplasty (THA) with intra-articular administration of tranexamic acid (TXA). We included 369 hips that underwent primary hybrid THA… read more here.
Keywords: propensity score; closed suction; articular administration; intra articular ... See more keywords
Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis
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DOI: 10.1038/s41598-018-34830-9
Abstract: Activation of NF-κB signaling promotes osteoarthritis (OA) through the transcriptional induction of Hif-2α and catabolic enzymes. This study sought to examine whether inhibiting IκBα kinase (IKK) could suppress the development of surgically-induced OA of the… read more here.
Keywords: articular administration; intra articular; bms 345541; hif axis ... See more keywords
Pharmacokinetic Assessment of Staphylococcal Phage K Following Parenteral and Intra-articular Administration in Rabbits
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DOI: 10.3389/fphar.2022.840165
Abstract: The therapeutic value of phage as an alternative to antibiotics for the treatment of bacterial infections is being considered in the wake of mounting antibiotic resistance. In this study, the pharmacokinetic properties of Staphylococcus aureus… read more here.
Keywords: articular administration; pharmacokinetic assessment; intra articular; phage following ... See more keywords
Candidates for Intra-Articular Administration Therapeutics and Therapies of Osteoarthritis
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DOI: 10.3390/ijms22073594
Abstract: Osteoarthritis (OA) of the knee is a disease that significantly decreases the quality of life due to joint deformation and pain caused by degeneration of articular cartilage. Since the degeneration of cartilage is irreversible, intervention… read more here.
Keywords: administration therapeutics; articular administration; therapies osteoarthritis; candidates intra ... See more keywords