Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase‐1 in human articular chondrocytes
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.04.018
Abstract: Abstract Osteoarthritis (OA) is common age‐associated disease, and associated with joint pain, mobility limitations and compromised overall quality of life. OA treatment is currently limited to pain management and joint arthroplasty at end stage disease.… read more here.
Keywords: cartilage degeneration; heme oxygenase; articular chondrocytes; human articular ... See more keywords
Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2017.12.020
Abstract: Osteoarthritis (OA) is a widely prevalent degenerative joint disease characterized by articular cartilage degradation and joint inflammation. The pathogenesis of OA remains unclear, leading to a lack of effective treatment. Previous studies have reported that… read more here.
Keywords: osteoarthritis; model; articular chondrocytes; expression ... See more keywords
PDLIM2 protects articular chondrocytes from lipopolysaccharide-induced apoptosis, degeneration and inflammatory injury through down-regulation of nuclear factor (NF)-κB signaling.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106883
Abstract: Excessive inflammatory response-induced apoptosis and the degeneration of articular chondrocytes contribute to the development and progression of osteoarthritis. PDZ and LIM domain containing protein 2 (PDLIM2) has emerged as one of the pivotal regulators in… read more here.
Keywords: apoptosis; pdlim2; articular chondrocytes; factor ... See more keywords
Complement component C1q is produced by isolated articular chondrocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.09.007
Abstract: OBJECTIVE Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory mediators reach chondrocytes is… read more here.
Keywords: c1q; articular chondrocytes; mrna expression; c1qa c1qb ... See more keywords
Thickness-wise growth technique for human articular chondrocytes to fabricate three-dimensional cartilage grafts
Sign Up to like & getrecommendations! Published in 2020 at "Regenerative Therapy"
DOI: 10.1016/j.reth.2019.12.001
Abstract: Introduction Cutting the cost of manufacturing is important for extending the use of tissue-engineered therapeutic products. The present study aimed to develop a simple method for fabrication of cartilaginous tissues for regenerative therapy, utilizing the… read more here.
Keywords: wise growth; thickness wise; articular chondrocytes; growth ... See more keywords
Gene expression markers in horse articular chondrocytes: Chondrogenic differentiaton IN VITRO depends on the proliferative potential and ageing. Implication for tissue engineering of cartilage.
Sign Up to like & getrecommendations! Published in 2019 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2019.10.024
Abstract: Chondrocyte dedifferentiation is a key limitation in therapies based on autologous chondrocyte implantation for cartilage repair. Articular chondrocytes, obtained from (metacarpophalangeal and metatarsophalangeal) joints of different aged horses, were cultured in monolayer for several passages… read more here.
Keywords: expression markers; gene expression; articular chondrocytes; expression ... See more keywords
Anti-inflammatory and chondroprotective effects of the S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin A, in human articular chondrocytes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06913-6
Abstract: Abstract3-Deazaneplanocin A (DZNep) is an inhibitor of S-Adenosyl-L-Homocysteine Hydrolase (SAHH) known to inhibit EZH2, a histone methylase upregulated during osteoarthritis. In this study, we assessed its effects in human articular chondrocytes. Anti-inflammatory effects were assessed… read more here.
Keywords: anti inflammatory; inhibitor; deazaneplanocin; dznep ... See more keywords
E3 Ubiquitin Ligase Constitutive Photomorphogenic 1 Regulates Differentiation and Inflammation via MAPK Signaling Pathway in Rabbit Articular Chondrocytes.
Sign Up to like & getrecommendations! Published in 2023 at "DNA and cell biology"
DOI: 10.1089/dna.2022.0664
Abstract: Constitutive photomorphogenic 1 (COP1), is an E3 ubiquitin ligase that plays a role in the regulation of various cellular processes including cell growth, differentiation, and survival in mammals. In certain conditions such as overexpression or… read more here.
Keywords: differentiation inflammation; regulates differentiation; ubiquitin ligase; articular chondrocytes ... See more keywords
Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14629
Abstract: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that eventually leads to joint deformities and loss of joint function. Previous studies have demonstrated a close relationship between autophagy and the development of RA. Although… read more here.
Keywords: autophagy apoptosis; adjuvant arthritis; apoptosis; articular chondrocytes ... See more keywords
Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential
Sign Up to like & getrecommendations! Published in 2018 at "Cartilage"
DOI: 10.1177/1947603518769714
Abstract: Objective To assess the phenotype of human articular chondrocytes cultured in normoxia (21% O2) or continuous hypoxia (2% O2). Design Chondrocytes were extracted from patients undergoing total knee replacement (n = 5) and cultured in… read more here.
Keywords: phenotype; normoxia promotes; immunomodulatory potential; chondrogenic potency ... See more keywords
Ethanol Alters Phenotype and Synthesis Activity of Rat Neonatal Articular Chondrocytes Grown in 2- and 3-Dimensional Culture.
Sign Up to like & getrecommendations! Published in 2019 at "Cartilage"
DOI: 10.1177/1947603519870862
Abstract: OBJECTIVE We sought to evaluate the effect of different concentrations of ethanol on phenotype and activity of articular chondrocyte synthesis of neonatal rats in 2-dimensional (2D) and 3-dimensional (3D) culture. METHODS Chondrocytes were cultured in… read more here.
Keywords: dimensional culture; articular chondrocytes; treated ethanol; culture ... See more keywords