Intra-articular injection of hUC-MSCs expressing miR-140-5p induces cartilage self-repairing in the rat osteoarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-019-01055-3
Abstract: Introduction Currently, osteoarthritis (OA) receives global increasing attention because it associates severe joint pain and serious disability. Stem cells intra-articular injection therapy showed a potential therapeutic superiority to reduce OA development and to improve treating… read more here.
Keywords: huc mscs; articular injection; mscs; intra articular ... See more keywords
Comparative evaluation of therapeutic efficacy of intra-articular oxaceprol with conventional modalities in osteoarthritis animal model
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Rheumatology"
DOI: 10.1007/s10067-018-4087-1
Abstract: The duration and dose-dependent side effects of conventional intra-articular corticosteroid treatment in osteoarthritis (OA) like cartilage damage and chondrocyte toxicity warrant the search for alternative therapeutics. Oxaceprol, a recognized oral therapeutic agent for osteoarthritis, is… read more here.
Keywords: comparative evaluation; oxaceprol; articular injection; articular oxaceprol ... See more keywords
MSC encapsulation in alginate microcapsules prolongs survival after intra-articular injection, a longitudinal in vivo cell and bead integrity tracking study
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-020-09532-6
Abstract: Mesenchymal stem cells (MSC) are promising candidates for use as a biological therapeutic. Since locally injected MSC disappear within a few weeks, we hypothesize that efficacy of MSC can be enhanced by prolonging their presence.… read more here.
Keywords: alginate; encapsulation alginate; articular injection; msc ... See more keywords
Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats.
Sign Up to like & getrecommendations! Published in 2017 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2017.06.002
Abstract: OBJECTIVE Disruptions of extracellular matrix (ECM) homeostasis are key events in the pathogenesis of osteoarthritis (OA). MicroRNA-140 (miRNA-140) is expressed specifically in cartilage and regulates ECM-degrading enzymes. Our objective in this study was to determine… read more here.
Keywords: mirna 140; ecm homeostasis; progression; articular injection ... See more keywords
Intra-articular injection of an antioxidant formulation did not improve structural degeneration in a rat model of post-traumatic osteoarthritis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Translation"
DOI: 10.1016/j.jot.2016.08.001
Abstract: Summary Background/objective Oxidative stress plays an important role in osteoarthritis (OA), causing inflammation and matrix degradation in joints. Previous studies have shown that antioxidants such as quercetin and vitamin C are potential candidates for treating… read more here.
Keywords: treatment; formulation; articular injection; post ... See more keywords
Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model
Sign Up to like & getrecommendations! Published in 2019 at "Drug Delivery"
DOI: 10.1080/10717544.2019.1568625
Abstract: Abstract Inflammation of the synovium and joint capsule is a main driver of pain in an osteoarthritic (OA) joint. Triamcinolone acetonide (TAA) is a classical corticosteroid that reduces synovitis and alleviates pain, albeit transiently. Biomaterial-based… read more here.
Keywords: taa loaded; inflammation; articular injection; taa ... See more keywords
Acupotomy combined with intra-articular injection of sodium hyaluronate in the treatment of knee osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030225
Abstract: This retrospective study aimed to compare the effects of acupotomy combined with intra-articular injection of sodium hyaluronate (IA-SH) for the treatment of knee osteoarthritis (KOA). Eighty electronic medical records of patients with KOA were retrospectively… read more here.
Keywords: acupotomy combined; articular injection; intra articular; injection sodium ... See more keywords
06.01 Intra-articular injection of cadmium protects arthritic joints from inflammation and destruction
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2016-211053.1
Abstract: Background There has been no recent progress in the intra-articular treatment of joint inflammation. Rheumatoid arthritis (RA) synovium hyperplasia is sustained by the secretion of pro-inflammatory cytokines (IL-17/TNF-α), synergistically contributing to chronicity. Since inflammation up-regulates… read more here.
Keywords: destruction; inflammation; articular injection; cadmium ... See more keywords
P111 Mesenchymal stem cell encapsulation in alginate micro-particles for intra-articular injection in osteoarthritis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-ewrr2018.126
Abstract: Introduction Owing to their ability to secrete anti-inflammatory and immuno-modulatory factors Mesenchymal Stromal Cells (MSCs) are an attractive tool for the treatment of osteoarthritis. Considering cell death and the risk of cell leakage upon intra-articular… read more here.
Keywords: alginate; articular injection; intra articular; cell ... See more keywords
Intra-Articular Injection of a Nanosuspension of Tetramethylpyrazine Dihydroxynaphthalenate for Stronger and Longer-Lasting Effects Against Osteoarthritis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2021.3094
Abstract: Tetramethylpyrazine (TMP), isolated from the rhizome of the traditional Chinese medicinal plant Chuanxiong (Ligusticum wallichii Franchat) shows therapeutic efficacy against osteoarthritis. After intra-articular injection, the retention time of TMP in the joint cavity is short,… read more here.
Keywords: nanosuspension; tetramethylpyrazine; articular injection; tmp ... See more keywords
Intra-articular Injection of Type I Atelocollagen to Alleviate Knee Pain: A Double-Blind, Randomized Controlled Trial.
Sign Up to like & getrecommendations! Published in 2019 at "Cartilage"
DOI: 10.1177/1947603519865304
Abstract: OBJECTIVE Collagen disruption is one of the underlying causes of knee pain in patients with osteoarthritis and/or diverse cartilage defects. Atelocollagen is a type of collagen that lacks telopeptides and thus has reduced antigenicity. The… read more here.
Keywords: articular injection; intra articular; knee pain; atelocollagen ... See more keywords