Biomimetic biodegradable artificial antigen presenting cells synergize with PD-1 blockade to treat melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2016.11.038
Abstract: Biomimetic materials that target the immune system and generate an anti-tumor responses hold promise in augmenting cancer immunotherapy. These synthetic materials can be engineered and optimized for their biodegradability, physical parameters such as shape and… read more here.
Keywords: melanoma; biomimetic biodegradable; blockade; artificial antigen ... See more keywords
Artificial Antigen Presenting Cells for Detection and Desensitization of Autoreactive T cells Associated with Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Nano Letters"
DOI: 10.1021/acs.nanolett.2c00819
Abstract: Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect… read more here.
Keywords: desensitization autoreactive; antigen presenting; type diabetes; artificial antigen ... See more keywords
Artificial Antigen-Presenting Cell Topology Dictates T Cell Activation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Nano"
DOI: 10.1021/acsnano.2c06211
Abstract: Nanosized artificial antigen-presenting cells (aAPCs), synthetic immune cell mimics that aim to activate T cells ex or in vivo, offer an effective alternative to cellular immunotherapies. However, comprehensive studies that delineate the effect of nano-aAPC… read more here.
Keywords: topology; cell; antigen presenting; artificial antigen ... See more keywords
DNA Engineered Lymphocyte-Based Homologous Targeting Artificial Antigen-Presenting Cells for Personalized Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c09316
Abstract: Artificial antigen-presenting cells (aAPCs) constructed by integrating T cell activation ligands on biocompatible materials hold great potential in tumor immunotherapy. However, it remains challenging to develop aAPCs, which could mimic the characteristics of natural APCs,… read more here.
Keywords: cell; dna; antigen presenting; artificial antigen ... See more keywords
Facile synthesis of polylactide coarse microspheres as artificial antigen-presenting cells.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc04958k
Abstract: Magnetic poly(l-lactide) coarse microspheres were synthesized via an emulsion method followed by chemical etching. Subsequently, anti-CD3 and anti-CD28 antibodies were attached to the microspheres via an avidin-biotin amplification system as artificial antigen-presenting cells. The activation… read more here.
Keywords: coarse microspheres; antigen presenting; artificial antigen; presenting cells ... See more keywords
DNA origami-based artificial antigen-presenting cells for adoptive T cell therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Science advances"
DOI: 10.1126/sciadv.add1106
Abstract: Nanosized artificial antigen-presenting cells (aAPCs) with efficient signal presentation hold great promise for in vivo adoptive cell therapy. Here, we used DNA origami nanostructures as two-dimensional scaffolds to regulate the spatial presentation of activating ligands… read more here.
Keywords: origami based; cell; dna; artificial antigen ... See more keywords