Technology used to build and transfer mammalian chromosomes.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111851
Abstract: In the near twenty-year existence of the human and mammalian artificial chromosome field, the technologies for artificial chromosome construction and installation into desired cell types or organisms have evolved with the rest of modern molecular… read more here.
Keywords: technology used; used build; human mammalian; transfer ... See more keywords
Panel of human cell lines with human/mouse artificial chromosomes
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-06814-3
Abstract: Human artificial chromosomes (HACs) and mouse artificial chromosomes (MACs) are non-integrating chromosomal gene delivery vectors for molecular biology research. Recently, microcell-mediated chromosome transfer (MMCT) of HACs/MACs has been achieved in various human cells that include… read more here.
Keywords: hacs macs; gene; cell; artificial chromosomes ... See more keywords
Combined use of bacterial artificial chromosomes-on-beads with karyotype detection improves prenatal diagnosis
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DOI: 10.1186/s13039-019-0416-6
Abstract: BackgroundThis study evaluated the individual and combined diagnostic performance of the bacterial artificial chromosomes (BACs)-on-Beads (BoBs™) assay and conventional karyotyping for the prenatal detection of chromosomal abnormalities in pregnant women who were 35 or more… read more here.
Keywords: detection; conventional karyotyping; artificial chromosomes; bacterial artificial ... See more keywords
Human Artificial Chromosomes and Their Transfer to Target Cells
Sign Up to like & getrecommendations! Published in 2022 at "Acta Naturae"
DOI: 10.32607/actanaturae.11670
Abstract: Human artificial chromosomes (HACs) have been developed as genetic vectors with the capacity to carry large transgenic constructs or entire gene loci. HACs represent either truncated native chromosomes or de novo synthesized genetic constructs. The… read more here.
Keywords: transfer target; human artificial; artificial chromosomes; target cells ... See more keywords