A comparison of the in vitro permeation of niacinamide in mammalian skin and in the Parallel Artificial Membrane Permeation Assay (PAMPA) model.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.11.065
Abstract: The in vitro skin penetration of pharmaceutical or cosmetic ingredients is usually assessed in human or animal tissue. However, there are ethical and practical difficulties associated with sourcing these materials; variability between donors may also… read more here.
Keywords: artificial membrane; permeation; skin; model ... See more keywords
Phosphatidylethanolamine functionalized biomimetic monolith for immobilized artificial membrane chromatography
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2021.09.002
Abstract: Abstract In this research, a new phospholipid based monolith was fabricated by in situ co-polymerization of 1-dodecanoyl-2-(11-methacrylamidoundecanoyl)-sn-glycero-3-phosphoethanolamine (MDSPE) and ethylene dimethacrylate (EDMA) to mimic bio-membrane environment. Excellent physicochemical properties of this novel monolith were achieved,… read more here.
Keywords: immobilized artificial; artificial membrane; phosphatidylethanolamine; biomimetic monolith ... See more keywords
Assessment of the Blood-Brain Barrier Permeability of Potential Neuroprotective Aurones in Parallel Artificial Membrane Permeability Assay and Porcine Brain Endothelial Cell Models.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2016.10.006
Abstract: Previously, several aurone derivatives were identified with promising neuroprotective activities. In developing these compounds to target the central nervous system (CNS), an assessment of their blood-brain barrier (BBB) permeability was performed using in vitro BBB models:… read more here.
Keywords: membrane permeability; artificial membrane; permeability; permeability assay ... See more keywords
Determination of in Vitro and in Silico Indexes for the Modeling of Blood-Brain Barrier Partitioning of Drugs via Micellar and Immobilized Artificial Membrane Liquid Chromatography.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01811
Abstract: In the present work, 79 structurally unrelated analytes were taken into account and their chromatographic retention coefficients, measured by immobilized artificial membrane liquid chromatography (IAM-LC) and by micellar liquid chromatography (MLC) employing sodium dodecyl sulfate… read more here.
Keywords: immobilized artificial; membrane liquid; liquid; artificial membrane ... See more keywords
31P and 1H NMR Studies of the Molecular Organization of Lipids in the Parallel Artificial Membrane Permeability Assay.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.6b00889
Abstract: The parallel artificial membrane permeability assay (PAMPA) has emerged as a widely used primary in vitro screen for passive permeability of potential drug candidates. However, the molecular structure of the permeation barrier (consisting of a… read more here.
Keywords: membrane permeability; pampa; artificial membrane; permeability ... See more keywords
Designer artificial membrane binding proteins to direct stem cells to the myocardium† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02650a
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc02650a
Abstract: We present a new cell membrane modification methodology where the inherent heart tissue homing properties of the infectious bacteria Streptococcus gordonii are transferred to human stem cells. read more here.
Keywords: designer artificial; artificial membrane; membrane binding; stem cells ... See more keywords
Characterization of the Penetration of the Blood–Brain Barrier by High-Performance Liquid Chromatography (HPLC) Using a Stationary Phase with an Immobilized Artificial Membrane
Sign Up to like & getrecommendations! Published in 2018 at "Analytical Letters"
DOI: 10.1080/00032719.2018.1424175
Abstract: ABSTRACT The biological activity of drugs on organisms is associated with the pharmacokinetic properties, such as the ability to penetrate through environments of varying polarity such as cellular organelles. In this area, particular attention is… read more here.
Keywords: blood brain; immobilized artificial; artificial membrane; blood ... See more keywords
Affinity of Compounds for Phosphatydylcholine-Based Immobilized Artificial Membrane—A Measure of Their Bioconcentration in Aquatic Organisms
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12111130
Abstract: The BCF (bioconcentration factor) of solutes in aquatic organisms is an important parameter because many undesired chemicals enter the ecosystem and affect the wildlife. Chromatographic retention factor log kwIAM obtained from immobilized artificial membrane (IAM)… read more here.
Keywords: artificial membrane; immobilized artificial; bioconcentration; aquatic organisms ... See more keywords
Usefulness of Artificial Membrane, Strat-M®, in the Assessment of Drug Permeation from Complex Vehicles in Finite Dose Conditions
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12020173
Abstract: The ban on the use of animals in testing cosmetic products has led to the development of animal-free in vitro methods. Strat-M® is an artificial membrane engineered to mimic human skin and is recommended as… read more here.
Keywords: artificial membrane; permeation; complex vehicles; finite dose ... See more keywords