Artificial Metalloenzymes on the Verge of New-to-Nature Metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2017.10.003
Abstract: Residing at the interface of chemistry and biotechnology, artificial metalloenzymes (ArMs) offer an attractive technology to combine the versatile reaction repertoire of transition metal catalysts with the exquisite catalytic features of enzymes. While earlier efforts… read more here.
Keywords: verge new; nature metabolism; chemistry; new nature ... See more keywords
Directed Evolution of Artificial Metalloenzymes: A Universal Means to Tune the Selectivity of Transition Metal Catalysts?
Sign Up to like & getrecommendations! Published in 2019 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.8b00582
Abstract: Transition metal catalysts mediate a wide variety of chemo-, stereo-, and regioselective transformations, and therefore play a pivotal role in modern synthetic organic chemistry. Steric and electronic effects of ligands provide organic chemists with an… read more here.
Keywords: transition metal; metal catalysts; metal; directed evolution ... See more keywords
Progress, Challenges, and Opportunities with Artificial Metalloenzymes in Biosynthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00829
Abstract: In this Perspective, we present progress, outstanding challenges, and opportunities for the incorporation of artificial metalloenzymes (ArMs) into biosynthetic pathways. We first explain discoveries within the field of ArMs that led to the potential inclusion… read more here.
Keywords: metalloenzymes biosynthesis; progress challenges; artificial metalloenzymes; opportunities artificial ... See more keywords
Artificial Metalloenzymes: Reaction Scope and Optimization Strategies.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.7b00014
Abstract: The incorporation of a synthetic, catalytically competent metallocofactor into a protein scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late 1970's. Progress in the ensuing years was limited by the tools… read more here.
Keywords: metalloenzymes reaction; catalyzed arms; artificial metalloenzymes; reactions catalyzed ... See more keywords
Engineering Thermostability in Artificial Metalloenzymes to Increase Catalytic Activity
Sign Up to like & getrecommendations! Published in 2021 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c05413
Abstract: Protein engineering has shown widespread use in improving the industrial application of enzymes and broadening the conditions they are able to operate under by increasing their thermostability and ... read more here.
Keywords: thermostability; thermostability artificial; metalloenzymes increase; engineering ... See more keywords
Chimeric Streptavidins as Host Proteins for Artificial Metalloenzymes
Sign Up to like & getrecommendations! Published in 2018 at "ACS Catalysis"
DOI: 10.1021/acscatal.7b03773
Abstract: The streptavidin scaffold was expanded with well-structured naturally occurring motifs. These chimeric scaffolds were tested as hosts for biotinylated catalysts as artificial metalloenzymes (ArM) for asymmetric transfer hydrogenation, ring-closing metathesis and anion−π catalysis. The additional… read more here.
Keywords: streptavidins host; proteins artificial; host proteins; artificial metalloenzymes ... See more keywords
Iridium(III) polypyridine artificial metalloenzymes with tunable photophysical properties: a new platform for visible light photocatalysis in aqueous solution.
Sign Up to like & getrecommendations! Published in 2023 at "Dalton transactions"
DOI: 10.1039/d3dt00932g
Abstract: Artificial metalloenzymes (ArMs) can combine the unique features of both metal complexes and enzymes by incorporating a cofactor within a protein scaffold. Herein, we describe a panel of ArMs constructed by covalently linking Ir(III) polypyridyl… read more here.
Keywords: light photocatalysis; photocatalysis; artificial metalloenzymes; cofactor ... See more keywords
Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis
Sign Up to like & getrecommendations! Published in 2021 at "Biological Chemistry"
DOI: 10.1515/hsz-2021-0329
Abstract: Abstract Artificial metalloenzymes combine the inherent reactivity of transition metal catalysis with the sophisticated reaction control of natural enzymes. By providing new opportunities in bioorthogonal chemistry and biocatalysis, artificial metalloenzymes have the potential to overcome… read more here.
Keywords: nutshell quartet; chemistry; quartet efficient; catalysis ... See more keywords
The Effect of Cofactor Binding on the Conformational Plasticity of the Biological Receptors in Artificial Metalloenzymes: The Case Study of LmrR
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2019.00211
Abstract: The design of Artificial Metalloenzymes (ArMs), which result from the incorporation of organometallic cofactors into biological structures, has grown steadily in the last two decades and important new-to-Nature reactions have been reached. These type of… read more here.
Keywords: effect cofactor; binding conformational; cofactor binding; artificial metalloenzymes ... See more keywords