Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells
Sign Up to like & getrecommendations! Published in 2024 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202300234
Abstract: Cell engineering strategies typically rely on energy‐consuming overexpression of genes or radical gene‐knock out. Both strategies are not particularly convenient for the generation of slightly modulated phenotypes, as needed in biosimilar development of for example… read more here.
Keywords: fucosylation; differentially fucosylated; artificial mirnas; cho production ... See more keywords
Artificial miRNAs as therapeutic tools: Challenges and opportunities
Sign Up to like & getrecommendations! Published in 2021 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1640
Abstract: RNA interference (RNAi) technology has been used for almost two decades to study gene functions and in therapeutic approaches. It uses cellular machinery and small, designed RNAs in the form of synthetic small interfering RNAs… read more here.
Keywords: challenges opportunities; artificial mirnas; pri mirna; therapeutic tools ... See more keywords