The Medicinal Chemistry of Artificial Nucleic Acids and Therapeutic Oligonucleotides
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DOI: 10.3390/ph15080909
Abstract: Nucleic acids play a central role in human biology, making them suitable and attractive tools for therapeutic applications. While conventional drugs generally target proteins and induce transient therapeutic effects, nucleic acid medicines can achieve long-lasting… read more here.
Keywords: medicinal chemistry; acids therapeutic; chemistry; artificial nucleic ... See more keywords
Hybrid-Type SELEX for the Selection of Artificial Nucleic Acid Aptamers Exhibiting Cell Internalization Activity
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13060888
Abstract: Nucleic acid aptamers have attracted considerable attention as next-generation pharmaceutical agents and delivery vehicles for small molecule drugs and therapeutic oligonucleotides. Chemical modification is an effective approach for improving the functionality of aptamers. However, the… read more here.
Keywords: artificial nucleic; hybrid type; acid; cell ... See more keywords