Artificial Organelles with Orthogonal‐Responsive Membranes for Protocell Systems: Probing the Intrinsic and Sequential Docking and Diffusion of Cargo into Two Coexisting Avidin–Polymersomes
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DOI: 10.1002/advs.202004263
Abstract: Abstract The challenge of effective integration and use of artificial organelles with orthogonal‐responsive membranes and their communication in eukaryotic protocells is to understand the intrinsic membrane characteristics. Here, a novel photo‐crosslinked and pH‐responsive polymersome (Psome… read more here.
Keywords: orthogonal responsive; artificial organelles; responsive membranes; organelles orthogonal ... See more keywords
Microliter Scale Synthesis of Luciferase‐Encapsulated Polymersomes as Artificial Organelles for Optogenetic Modulation of Cardiomyocyte Beating
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DOI: 10.1002/advs.202200239
Abstract: Constructing artificial systems that effectively replace or supplement natural biological machinery within cells is one of the fundamental challenges underpinning bioengineering. At the sub‐cellular scale, artificial organelles (AOs) have significant potential as long‐acting biomedical implants,… read more here.
Keywords: microliter scale; modulation; artificial organelles; synthesis ... See more keywords
Probing Crowdedness of Artificial Organelles by Clustering Polymersomes for Spatially Controlled and pH-Triggered Enzymatic Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00546
Abstract: Most sophisticated biological functions and features of cells are based on self-organization, and the coordination and connection between their cell organelles determines their key functions. Therefore, spatially ordered and controllable self-assembly of polymersomes to construct… read more here.
Keywords: polymersomes spatially; crowdedness artificial; probing crowdedness; artificial organelles ... See more keywords
Biomolecular Condensate-Based Artificial Organelle for Driving Compartmentalized Flux Control.
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DOI: 10.1021/acssynbio.4c00871
Abstract: Microbial cell factories have emerged as versatile bioreactors capable of orchestrating complex metabolic networks to convert renewable feedstocks into high-value biochemicals. Nevertheless, the diffusion-mediated dispersion of metabolic intermediates often compromises biosynthesis efficiency, primarily attributable to… read more here.
Keywords: flux control; biomolecular condensate; biology; artificial organelles ... See more keywords
In Situ Synthesis of Multifunctional 3D Polymeric Artificial Organelles in Living Cells.
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DOI: 10.1021/jacs.5c08624
Abstract: Artificial organelles have been developed to restore dysfunction or to introduce new-to-nature functions to the host cells, although limitations, such as instability, still exist. Here, we develop a new strategy to fabricate structurally stable polymeric… read more here.
Keywords: situ synthesis; multifunctional polymeric; polymeric artificial; artificial organelles ... See more keywords
Stimuli-responsive vesicles as distributed artificial organelles for bacterial activation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206563119
Abstract: Significance Artificial cells are entities designed to mimic biological cells in form and function. One of the grand challenges of this field is engineering “nonliving” artificial cells to communicate with their biological “living” counterparts. Combining… read more here.
Keywords: stimuli responsive; responsive vesicles; artificial cells; artificial organelles ... See more keywords