Design and synthesis of novel pyridazine N-aryl acetamides: In-vitro evaluation of α-glucosidase inhibition, docking, and kinetic studies.
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DOI: 10.1016/j.bioorg.2020.104071
Abstract: We herein applied the four step-synthetic route to prepare the pyridazine core attached to the various N-aryl acetamides. By this approach, a new series of pyridazine-based compounds were synthesized, characterized and evaluated for their activities… read more here.
Keywords: aryl acetamides; kinetic studies; docking kinetic; pyridazine ... See more keywords
A mild and efficient synthesis of N-aryl glycines by the rearrangement of 2-chloro-N-aryl acetamides
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DOI: 10.1039/d5ra02497h
Abstract: A mild and efficient one-pot procedure was developed for the synthesis of substituted N-aryl glycines from 2-chloro-N-aryl acetamides by intermolecular cyclization in the presence of CuCl2·2H2O and KOH under reflux condition in acetonitrile medium. The… read more here.
Keywords: aryl glycines; aryl acetamides; mild efficient; chloro aryl ... See more keywords