The inexpensive additive N-methylmorpholine effectively decreases the equivalents of nucleophiles in the catalytic highly enantioselective arylation of aryl aldehydes.
Sign Up to like & getrecommendations! Published in 2017 at "Chirality"
DOI: 10.1002/chir.22709
Abstract: Highly enantioselective arylation of aryl aldehydes catalyzed by (S)-H8 -BINOL-Ti(Oi-Pr)2 complex in the presence of N-methylmorpholine (NMM) as an effective and inexpensive additive is described for the first time. We found high enantioselectivity and yield… read more here.
Keywords: equivalents nucleophiles; enantioselective arylation; arylation aryl; aryl aldehydes ... See more keywords
Efficient chemoenzymatic synthesis of α-aryl aldehydes as intermediates in C-C bond forming biocatalytic cascades.
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DOI: 10.1021/acscatal.2c02369
Abstract: Multi-enzyme biocatalytic cascades are emerging as practical routes for the synthesis of complex bioactive molecules. However, the relative sparsity of water-stable carbon electrophiles limits the synthetic complexity of molecules made from such cascades. Here, we… read more here.
Keywords: biocatalytic cascades; aryl aldehydes; bond forming; synthesis ... See more keywords
An umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles
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DOI: 10.1039/d2sc00046f
Abstract: We have described the first example of an umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition between two aryl aldehydes and a nitrile under the influence of TMSOTf that proceeds through the formation… read more here.
Keywords: strategy intermolecular; intermolecular cycloaddition; trisubstituted oxazoles; umpolung strategy ... See more keywords
Carbene reactivity from alkyl and aryl aldehydes
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DOI: 10.1126/science.abo6443
Abstract: Carbenes are highly enabling reactive intermediates that facilitate a diverse range of otherwise inaccessible chemistry, including small-ring formation and insertion into strong σ bonds. To access such valuable reactivity, reagents with high entropic or enthalpic… read more here.
Keywords: reactivity alkyl; carbene reactivity; reactivity; alkyl aryl ... See more keywords