Palladium‐Catalyzed C−H Alkenylation of α‐Aryl Alkyl Nitriles
Sign Up to like & getrecommendations! Published in 2024 at "ChemCatChem"
DOI: 10.1002/cctc.202301730
Abstract: A direct α‐alkenylation of nitrile compounds was realized with a palladium complex. This method exhibited excellent tolerance toward a variety of α‐aryl alkyl nitriles and vinyl bromides, leading to the formation of a series of… read more here.
Keywords: aryl alkyl; alkenylation; alkyl nitriles; palladium catalyzed ... See more keywords
Synthesis of N-aryl and N-alkyl substituted imidazolium silver complexes. Cytotoxic screening using human cell lines modelling acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000138
Abstract: A series of N- aryl and N- alkyl substituted imidazoles were synthesized and complexed with Ag + to obtain silver-NHC complexes of the form [Ag(NHC)2 ]X. These silver-NHC complexes were tested in-vitro versus the human… read more here.
Keywords: alkyl substituted; cell lines; myeloid leukemia; aryl alkyl ... See more keywords
Synthesis of di- and trihydroxy proline derivatives from D-glycals: Application in the synthesis of polysubstituted pyrrolizidines and bioactive 1C-aryl/alkyl pyrrolidines.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate research"
DOI: 10.1016/j.carres.2019.02.004
Abstract: Six different types of O-benzyl protected proline derivatives have been synthesized from D-glycals and 2C-formyl-glycals. One of the di-O-benzyl protected proline derivatives has been utilized for the synthesis of polysubstituted pyrrolizidines via [3 + 2] cycloaddition in… read more here.
Keywords: synthesis polysubstituted; synthesis; proline derivatives; aryl alkyl ... See more keywords
Nucleophilic Amination and Etherification of Aryl Alkyl Thioethers.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01758
Abstract: A transition-metal-free protocol capable of synthesizing diarylated aniline derivatives is reported. This method could be further employed to prepare aryl alkyl ethers. A wide range of thioethers, anilines, as well as alcohols were tolerated thanks… read more here.
Keywords: alkyl thioethers; amination etherification; nucleophilic amination; aryl alkyl ... See more keywords
Design, Synthesis, and Pharmacological Evaluation of Embelin-Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood-Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer's Disease: Discovery of SB-1448.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00030
Abstract: The complex and multifaceted nature of Alzheimer's disease has brought about a pressing demand to develop ligands targeting multiple pathways to combat its outrageous prevalence. Embelin is a major secondary metabolite of Embelia ribes Burm… read more here.
Keywords: amine hybrids; alzheimer disease; alkyl amine; embelin aryl ... See more keywords
Aryl-Alkyl-Lysines Interact with Anionic Lipid Components of Bacterial Cell Envelope Eliciting Anti-Inflammatory and Antibiofilm Properties
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b01052
Abstract: The emergence of bacterial resistance and hesitance in approving new drugs has bolstered research on membrane-active agents such as antimicrobial peptides and their synthetic derivatives as therapeutic alternatives against bacterial infections. Herein, we document the… read more here.
Keywords: aryl alkyl; lysines interact; anionic lipid; interact anionic ... See more keywords
One-Pot Synthesis of 2-(Het)aryl/alkyl-3-cyanobenzofurans from 2-(2-Bromoaryl)-3-(het)aryl-3-(methylthio)acrylonitriles and Benzyl Carbamate
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b01172
Abstract: A one-pot synthesis of 2-(het)aryl/alkyl-3-cyanobenzofurans has been reported. The overall sequence involves base-induced reaction of 2-(2-bromoaryl)-3-(het)aryl-3-(methylthio)acrylonitriles with benzyl carbamate, generating α-(het)aroyl-α-(2-bromoaryl)acetonitriles, which are in situ subjected to copper-catalyzed intramolecular O-arylation, furnishing the 2-(het)aryl/alkyl-3-cyanobenzofurans in high… read more here.
Keywords: bromoaryl het; aryl alkyl; het aryl; aryl ... See more keywords
Catalytic Activation of Unstrained C(Aryl)-C(Alkyl) Bonds in 2,2'-Methylenediphenols.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c13342
Abstract: Catalytic activation of unstrained and nonpolar C-C bonds remains a largely unmet challenge. Here, we describe our detailed efforts in developing a rhodium-catalyzed hydrogenolysis of unstrained C(aryl)-C(alkyl) bonds in 2,2'-methylenediphenols aided by removable directing groups.… read more here.
Keywords: unstrained aryl; activation unstrained; bonds methylenediphenols; aryl alkyl ... See more keywords
Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols
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DOI: 10.1021/jacs.5c02981
Abstract: We introduce aryl thiols as nucleophiles for site-specific protein and antibody bioconjugation, which allows the orthogonal labeling of native cysteines for double modification strategies. In a high-yielding synthesis, we introduce aromatic thiol substituents in two… read more here.
Keywords: aryl alkyl; site; aryl; dual bioconjugation ... See more keywords
Ligand-controlled regiodivergent arylation of aryl(alkyl)alkynes and asymmetric synthesis of axially chiral 9-alkylidene-9,10-dihydroanthracenes
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-53767-4
Abstract: Transition metal-catalyzed addition of organometallics to aryl(alkyl)alkynes has been well known to proceed with the regioselectivity in forming a carbon–carbon bond at the alkyl-substituted carbon (β-addition). Herein, the reverse regiochemistry with high selectivity in giving… read more here.
Keywords: alkyl alkynes; axially chiral; aryl alkyl; addition ... See more keywords
Aryl-alkyl-lysines: small molecular membrane-active antiplasmodial agents.
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DOI: 10.1039/c6md00589f
Abstract: Due to emerging resistance there is a steady need for new antimalarial drugs. Here, we report a new class of water soluble, non-toxic compounds, aryl-alkyl-lysines, with promising activity against the ring stage of Plasmodium falciparum.… read more here.
Keywords: aryl alkyl; small molecular; molecular membrane; alkyl lysines ... See more keywords