Copper-Catalyzed Formal Transfer Hydrogenation/Deuteration of Aryl Alkynes.
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DOI: 10.1021/acs.orglett.0c03632
Abstract: A copper-catalyzed reduction of alkynes to alkanes and deuterated alkanes is described under transfer hydrogenation and transfer deuteration conditions. Commercially available alcohols and silanes are used interchangeably with their deuterated analogues as the hydrogen or… read more here.
Keywords: deuteration; transfer hydrogenation; aryl alkynes; transfer ... See more keywords
Modular Synthesis of 9,10-Dihydroacridines through an ortho-C Alkenylation/Hydroarylation Sequence between Anilines and Aryl Alkynes in Hexafluoroisopropanol.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00487
Abstract: 9,10-Dihydroacridines are frequently encountered as key scaffolds in OLEDs. However, accessing those compounds from feedstock precursors typically requires multiple steps. Herein, a modular one-pot synthesis of 9,10-dihydroacridine frameworks is achieved through a reaction sequence featuring… read more here.
Keywords: hydroarylation; ortho alkenylation; aryl alkynes; sequence ... See more keywords
Electrochemical E-Selective Semireductive Dicarboxylation of Aryl Alkynes with CO2.
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DOI: 10.1021/acs.orglett.4c00860
Abstract: Herein, we report an electrochemical protocol for the dicarboxylation of aryl alkynes using CO2. With a graphite rod as the cathode and Al as the sacrificial anode, a series of valuable butenedioic acids are obtained… read more here.
Keywords: electrochemical selective; selective semireductive; aryl alkynes; dicarboxylation aryl ... See more keywords
Regioselective Cu-Catalyzed Hydrosilylation of Internal Aryl Alkynes.
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DOI: 10.1021/acs.orglett.4c04722
Abstract: Construction of vinylsilane building blocks is important for advancing the synthesis of complex small molecules and natural products. Herein, we report a highly regio- and stereoselective copper-catalyzed hydrosilylation of unsymmetrical internal aryl alkynes. The reaction… read more here.
Keywords: internal aryl; catalyzed hydrosilylation; regioselective catalyzed; aryl alkynes ... See more keywords
Reductive Ni-catalysis for stereoselective carboarylation of terminal aryl alkynes.
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DOI: 10.1039/d1cc04586e
Abstract: Stereoselective dicarbofunctionalization of terminal aryl alkynes has been achieved through reductive Ni-catalysis. The exclusive regioselective and anti-addition selective alkylarylation of terminal alkynes is accomplished using alkyl iodide and aryl iodide as electrophilic coupling partners in… read more here.
Keywords: reductive catalysis; terminal; terminal aryl; aryl alkynes ... See more keywords
Acid-promoted intra- and intermolecular [2+2] cycloaddition of indoles to aryl alkynes to access cyclobutene-fused indolines.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02840a
Abstract: Herein, we have reported the first example of both intra- and intermolecular [2+2] cycloaddition of the electron-rich indoles and unactivated aryl alkynes promoted by the combination of Fe(NO3)3 and HNO3, which highlights efficient and selective… read more here.
Keywords: fused indolines; cyclobutene fused; intermolecular cycloaddition; aryl alkynes ... See more keywords
Hydrogen-Bond-Promoted Friedel–Crafts Reaction of Secondary Propargylic Fluorides: Preparation of 1-Alkyl-1-aryl-2-alkynes
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DOI: 10.1055/s-0036-1589057
Abstract: We report that aromatic propargylation is achievable with secondary propargylic fluorides, thus affording 1-alkyl-1-aryl-2-alkynes. In the present case, hydrogen bonding is responsible for the activation of the C–F bond. A large excess of arene nucleophile… read more here.
Keywords: secondary propargylic; hydrogen bond; aryl alkynes; propargylic fluorides ... See more keywords