Synthesis, molecular modeling studies and anticonvulsant activity of certain (1-(benzyl (aryl) amino) cyclohexyl) methyl esters.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.01.021
Abstract: A series of (1-(benzyl (aryl) amino) cyclohexyl) methyl esters 7a-n were prepared and screened for their anticonvulsant profile. Screening of these esters 7a-n and their starting alcohols 6a and 6b revealed that compound 7k was… read more here.
Keywords: methyl esters; amino cyclohexyl; aryl amino; cyclohexyl methyl ... See more keywords
Cyclic (Alkyl)- and (Aryl)-(amino)carbene Coinage Metal Complexes and Their Applications.
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DOI: 10.1021/acs.chemrev.0c00043
Abstract: Cyclic (alkyl)- and (aryl)-(amino)carbenes (CAACs and CAArCs) are stronger σ-donors and π-acceptors than imidazol-2-ylidenes and imidazolidin-2-ylidenes, the well-known N-heterocyclic carbenes (NHCs). Consequently, they form strong bonds with coinage metals and stabilize both low and high… read more here.
Keywords: aryl amino; coinage metal; coinage; alkyl aryl ... See more keywords
Photo-Induced N-N Coupling of o-Nitrobenzyl Alcohols and Indolines To Give N-Aryl-1-amino Indoles.
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DOI: 10.1021/acs.orglett.1c02227
Abstract: A novel method to synthesize N-aryl-1-amino indoles was established by the photoinduced N-N coupling reaction. This protocol is by treatment of o-nitrobenzyl alcohols and indolines in the presence of TEAI and acetic acid with a… read more here.
Keywords: aryl amino; nitrobenzyl alcohols; amino indoles; alcohols indolines ... See more keywords
Relay Photocatalytic Reaction of N-Aryl Amino Acids and 2-Bromo-3,3,3-trifluoropropene: Synthesis of 4-(Difluoromethylidene)-tetrahydroquinolines.
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DOI: 10.1021/acs.orglett.2c01117
Abstract: The bulk industrial chemical 2-bromo-3,3,3-trifluoropropene (BTP) was first employed as a coupling partner in photocatalytic defluorinative reactions with N-aryl amino acids. Photoredox activation of the C(sp2)-Br bond of the resultant 2-bromo-1,1-difluoroalkenes generates gem-difluoro vinyl radicals… read more here.
Keywords: amino acids; difluoromethylidene tetrahydroquinolines; bromo trifluoropropene; aryl amino ... See more keywords
Kinetic resolution of N-aryl β-amino alcohols via asymmetric aminations of anilines.
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DOI: 10.1039/d1cc03117a
Abstract: An efficient kinetic resolution of N-aryl β-amino alcohols has been developed via asymmetric para-aminations of anilines with azodicarboxylates enabled by chiral phosphoric acid catalysis. Broad substrate scope and high kinetic resolution performances were afforded with… read more here.
Keywords: resolution; aryl amino; kinetic resolution; resolution aryl ... See more keywords