Asymmetric synthesis of 4-aryl dihydroisoquinolin-3-ones and 2-aryl morpholin-3-ones using AgOTf-activated α-bromo arylacetate
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DOI: 10.1016/j.tet.2019.130841
Abstract: Abstract A novel asymmetric synthetic strategy to prepare 4-aryl-dihydroisoquinolinones has been developed through a highly regioselective Friedel-Crafts alkylation of benzylamine derivatives with (αR)-α-bromo arylacetates and subsequent facile lactamization. In addition, an efficient asymmetric synthesis of… read more here.
Keywords: dihydroisoquinolin ones; synthesis aryl; aryl dihydroisoquinolin; asymmetric synthesis ... See more keywords