Behavioural and pharmacological profiles of zebrafish administrated pyrrolidinyl benzodioxanes and prolinol aryl ethers with high affinity for heteromeric nicotinic acetylcholine receptors
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05536-6
Abstract: Rationale Prolinol aryl ethers and their rigidified analogues pyrrolidinyl benzodioxanes have a high affinity for mammalian α4β2 nicotinic acetylcholine receptors (nAChRs). Electrophysiological studies have shown that the former are full agonists and the latter partial… read more here.
Keywords: aryl ethers; high affinity; prolinol aryl; agonist ... See more keywords
Iron-Catalyzed Borylation of Aryl Ethers via Cleavage of C-O Bonds.
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DOI: 10.1021/acs.orglett.0c00679
Abstract: Herein, we report the iron-catalyzed borylation of aryl ethers and aryl amines via cleavage of C-O and C-N bonds. This protocol does not require the use of Grignard reagents and displays a broad substrate scope,… read more here.
Keywords: aryl ethers; catalyzed borylation; borylation; via cleavage ... See more keywords
Gold(I) Catalyzed Dearomative Claisen Rearrangement of Allyl, Allenyl Methyl, and Propargyl Aryl Ethers.
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DOI: 10.1021/acs.orglett.7b03306
Abstract: Claisen rearrangements of allyl aryl ethers to generate enones bearing all carbon quaternary centers are accelerated by Ph3PAuNTf2 under mild conditions in good yields. Multiple C-C bond containing variants of the allyl fragment are viable,… read more here.
Keywords: aryl ethers; claisen; dearomative claisen; allyl ... See more keywords
Palladium-catalyzed synthesis of 4-cyclohexylmorpholines from reductive coupling of aryl ethers and lignin model compounds with morpholines
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DOI: 10.1039/d0gc03188g
Abstract: This work describes the highly efficient Pd-catalyzed direct coupling of aryl ethers (including the typical lignin model compounds) and morpholines to produce 4-cyclohexylmorpholines, a useful class of fine chemicals. Without employing any acidic additives, various… read more here.
Keywords: aryl ethers; model compounds; compounds morpholines; coupling aryl ... See more keywords
para-Selective hydroxylation of alkyl aryl ethers.
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DOI: 10.1039/d1cc06210g
Abstract: para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(II) catalyst, hypervalent iodine(III) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile… read more here.
Keywords: aryl ethers; hydroxylation alkyl; para selective; selective hydroxylation ... See more keywords
Carbodiimides as Acid Scavengers in Aluminum Triiodide Induced Cleavage of Alkyl Aryl Ethers
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DOI: 10.1055/s-0036-1588755
Abstract: A practical procedure for the cleavage of alkyl aryl ethers containing labile functional groups has been developed using aluminum triiodide as the ether cleaving reagent. Carbodiimides, typically used as dehydration reagents for the coupling of… read more here.
Keywords: aryl ethers; alkyl aryl; cleavage alkyl; aluminum triiodide ... See more keywords