Synthesis of naphthyl-substituted terminal olefins via Pd-Catalyzed one-pot coupling of acetylnaphthalene, N-Tosylhydrazide with aryl halide
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.09.052
Abstract: Abstract In this study, a one-pot two-step Pd-catalyzed reductive eliminate between acetyl naphthalene derivatives, tosylhydrazide, and aryl halide, affording substituted 1(or 2)-(1-phenylvinyl)naphthalene in moderate-to-excellent yields, was reported. Notably, solvent played a crucial role in the… read more here.
Keywords: pot; tosylhydrazide aryl; aryl halide; one pot ... See more keywords
Mechanistic Interrogation of Photochemical Nickel-Catalyzed Tetrahydrofuran Arylation Leveraging Enantioinduction Data.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c13485
Abstract: This manuscript details the development of an asymmetric variant for the Ni-photoredox α-arylation of tetrahydrofuran (THF), which was originally reported in a racemic fashion by Doyle and Molander. Leveraging the enantioselectivity data that we obtained,… read more here.
Keywords: photochemical nickel; mechanistic interrogation; interrogation photochemical; enantioselectivity ... See more keywords
Sterically Induced Acceleration of Aryl Halide Activation by Pd(0): A Radical Alternative to 2‑Electron Oxidative Addition
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c04407
Abstract: The first elementary step of Pd(0)-catalyzed cross-coupling involves the activation of an aryl halide by a Pd(0) catalyst, which is widely assumed to proceed in a formal 2-electron process, involving concerted cleavage of the aryl… read more here.
Keywords: sterically induced; aryl halide; electron; activation ... See more keywords