Catalytic enantioselective synthesis of α-aryl α-hydrazino esters and amides.
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DOI: 10.1039/d0cc02478c
Abstract: Catalysts generated by combinations of Pd(TFA)2 and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of aryl boronic acids to N-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding α-aryl α-hydrazino esters/amides in high enantioselectivities. Subsequent removal… read more here.
Keywords: catalytic enantioselective; aryl hydrazino; hydrazino esters; esters amides ... See more keywords