Rational Design and Synthesis of 1‐(Arylideneamino)‐4‐aryl‐1H‐imidazole‐2‐amine Derivatives as Antiplatelet Agents
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DOI: 10.1002/cmdc.201700123
Abstract: Based on previous studies indicating the pharmacophoric role of a hydrazone group and azole rings for antiplatelet aggregation activity, a few series of compounds with both hydrazone and an azole (imidazole) ring in their structures… read more here.
Keywords: amine derivatives; aggregation; aryl imidazole; imidazole amine ... See more keywords
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors
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DOI: 10.3390/molecules26164718
Abstract: A novel series of tri-aryl imidazole derivatives 5a–n carrying benzene sulfonamide moiety has been designed for their selective inhibitory against hCA IX and XII activity. Six compounds were found to be potent and selective CA… read more here.
Keywords: biological evaluation; aryl imidazole; benzene sulfonamide; xii ... See more keywords