Copper-Catalyzed Asymmetric Hydrosilylation of β-Nitroethyl Aryl Ketones.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04339
Abstract: A copper-catalyzed asymmetric hydrosilylation of β-nitroethyl aryl ketones has been disclosed, and the corresponding chiral alcohols could be obtained in high yields (up to 99% yield) and excellent enantioselectivities (up to 96% ee). Moreover, the… read more here.
Keywords: catalyzed asymmetric; copper catalyzed; aryl ketones; asymmetric hydrosilylation ... See more keywords
Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones
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DOI: 10.1021/acsomega.7b00713
Abstract: We disclose the synthesis of a series of manganese complexes of chiral iminopyridine oxazoline ligands and their application in the first manganese-catalyzed asymmetric ketone hydrosilylations. The most sterically hindered manganese catalyst bearing two CH(Ph)2 groups… read more here.
Keywords: catalyzed asymmetric; manganese catalyzed; aryl ketones; hydrosilylation aryl ... See more keywords
C3-Arylation of indoles with aryl ketones via C-C/C-H activations.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc03954g
Abstract: C3-Arylation of indoles with aryl ketones is accomplished via palladium-catalyzed ligand-promoted Ar-C(O) cleavage and subsequent C-H arylation of indole. Various (hetero)aryl ketones are compatible in this reaction, affording the corresponding 3-arylindoles in moderate to good… read more here.
Keywords: ketones via; aryl ketones; arylation indoles; via activations ... See more keywords
Nickel-catalyzed cross-coupling of epoxides with aryltriflates: rapid and regioselective construction of aryl ketones.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02891c
Abstract: Aryl ketones are one of the most important classes of organic compounds, and widely present in various pharmacological compounds, biologically active molecules and functional materials. Presented herein is a facile synthetic method for the construction… read more here.
Keywords: aryl ketones; epoxides aryltriflates; cross coupling; coupling epoxides ... See more keywords
Preparation of Chiral α-Aryl Ketones and Aldehydes via Ni-Catalyzed Asymmetric Cross-Electrophile Coupling
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DOI: 10.1055/a-2726-4625
Abstract: The preparation of tertiary α-aryl acetals and ketals has been achieved through a Ni-catalyzed reductive cross-coupling approach, utilizing a readily available Ni/Biox catalytic platform. This reaction demonstrates effective enantioselective control over unactivated alkyl radicals adjacent… read more here.
Keywords: ketones aldehydes; preparation chiral; aryl; aryl ketones ... See more keywords
Bile-Acid-Appended Triazolyl Aryl Ketones: Design, Synthesis, In Vitro Anticancer Activity and Pharmacokinetics in Rats
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DOI: 10.3390/molecules26195741
Abstract: A library of bile-acid-appended triazolyl aryl ketones was synthesized and characterized by detailed spectroscopic techniques such as 1H and 13C NMR, HRMS and HPLC. All the synthesized conjugates were evaluated for their cytotoxicity at 10… read more here.
Keywords: appended triazolyl; aryl ketones; triazolyl aryl; acid appended ... See more keywords