Exploring the Selective Demethylation of Aryl Methyl Ethers with a Pseudomonas Rieske Monooxygenase
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800594
Abstract: Biocatalytic dealkylation of aryl methyl ethers is an attractive reaction for valorization of lignin components, as well as for deprotection of hydroxy functionalities in synthetic chemistry. We explored the demethylation of various aryl methyl ethers… read more here.
Keywords: rieske monooxygenase; aryl methyl; methyl ethers; demethylation ... See more keywords
Novel Approach to the Synthesis of 3-amino-4-arylpyridin-2(1H)-one Derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-021-02980-w
Abstract: The reaction of 4-arylidene-2-phenyloxazol-5(4H)-ones with enamines of ethyl acetoacetate gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylic acid esters, which, when heated with phosphorus oxychloride, were converted into esters of 7-aryl-5-methyl-2-phenyloxazolo[5,4-b]pyridine-6-carboxylic acids. Alkaline hydrolysis of these compounds gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,6-dihydropyridine-3-carboxylic acid esters. read more here.
Keywords: aryl methyl; amino; novel approach; synthesis amino ... See more keywords
A Simple Process for the Synthesis of Novel Pyrazolyltriazole and Dihydropyrazolylthiazole Derivatives as Antimicrobial Agents
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal for Science and Engineering"
DOI: 10.1007/s13369-017-2530-2
Abstract: Series of novel 1,2-bis((3-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazol-4-yl)methylene) hydrazines 4 and 2-(5-(3-(1,2,3-triazol-4-yl)pyrazol-4-yl) pyrazol-1-yl)thiazoles 13 were synthesized using simple and convenient procedures, and their structures were established. Treatment of pyrazole-4-carbaldehydes 1 with methyl ketones in alkaline medium gave the corresponding… read more here.
Keywords: synthesis novel; aryl methyl; pyrazol; gave corresponding ... See more keywords
A novel synthesis of aryl methyl sulfones and β-hydroxysulfones from sodium sulfinates and di-tert-butyl peroxide in H2O medium
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.12.074
Abstract: Abstract A novel and convenient synthetic route for aryl methyl sulfones and β -hydroxysulfones was developed via the radical reaction between sodium sulfinates and di- tert -butyl peroxide (DTBP). Without any catalysts and additives, the… read more here.
Keywords: aryl methyl; sulfinates tert; methyl sulfones; sodium sulfinates ... See more keywords
Contrasting Mechanisms of Aromatic and Aryl-Methyl Substituent Hydroxylation by the Rieske Monooxygenase Salicylate 5-Hydroxylase.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00610
Abstract: The hydroxylase component (S5HH) of salicylate-5-hydroxylase catalyzes C5 ring hydroxylation of salicylate but switches to methyl hydroxylation when a C5 methyl substituent is present. The use of 18O2 reveals that both aromatic and aryl-methyl hydroxylations… read more here.
Keywords: salicylate; aromatic aryl; aryl methyl; hydroxylation ... See more keywords
Selectfluor-Promoted Reactions of Aryl Methyl Ketones with Dimethyl Sulfoxide to Give 2,5-Diacylthiophenes and β-Acyl Allylic Methylsulfones.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04101
Abstract: In this paper, a convenient synthesis of 2,5-diacylthiophenes and β-acyl allylic methylsulfones from aryl methyl ketones with dimethyl sulfoxide (DMSO) through Selectfluor-promoted cascade cyclization and cross-coupling reactions by simple solvent modification is described. This method… read more here.
Keywords: ketones dimethyl; aryl methyl; diacylthiophenes acyl; acyl allylic ... See more keywords
Microwave-mediated stereocontrolled annulations of diazo(aryl)methyl(diaryl)phosphine oxides with pyridinium 1,4-zwitterionic thiolates.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc05483c
Abstract: Chemoselective annulations of phosphoryl carbenes generated from diazo(aryl)methyl(diaryl)phosphine oxides with pyridinium 1,4-zwitterionic thiolates were performed under microwave irradiation, affording 1-diarylphosphoryl-1H-benzo[c]thiopyran derivatives via [3+3] annulation and indolizine derivatives via ([1+5]-1) annulation with P-Cope elimination as the… read more here.
Keywords: pyridinium zwitterionic; aryl methyl; diazo aryl; zwitterionic thiolates ... See more keywords
Nickel-Catalyzed Amination of α-Aryl Methyl Ethers
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DOI: 10.1055/s-0039-1690718
Abstract: α-Aryl amines are prevalent in pharmaceutically active compounds and natural products. Herein, we describe a Ni-catalyzed protocol for their synthesis from readily available α-aryl ethers. While α-aryl ethers have been used as electrophiles in Ni-catalyzed… read more here.
Keywords: aryl methyl; methyl ethers; catalyzed amination; amination aryl ... See more keywords
QSAR, ADMET In Silico Pharmacokinetics, Molecular Docking and Molecular Dynamics Studies of Novel Bicyclo (Aryl Methyl) Benzamides as Potent GlyT1 Inhibitors for the Treatment of Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15060670
Abstract: Forty-four bicyclo ((aryl) methyl) benzamides, acting as glycine transporter type 1 (GlyT1) inhibitors, are developed using molecular modeling techniques. QSAR models generated by multiple linear and non-linear regressions affirm that the biological inhibitory activity against… read more here.
Keywords: molecular docking; aryl methyl; glyt1 inhibitors; methyl benzamides ... See more keywords