SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX.
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DOI: 10.1016/j.bioorg.2018.11.014
Abstract: SLC-0111, an ureido substituted benzenesulfonamide, is a selective carbonic anhydrase (CA, EC 4.2.1.1) IX inhibitor that is currently in Phase I/II clinical trials for the treatment of advanced hypoxic tumors complicated with metastases. Herein we… read more here.
Keywords: slc 0111; carbonic anhydrase; oxopropenyl aminobenzenesulfonamides; aryl oxopropenyl ... See more keywords