Rapid Boulton–Katritzky rearrangement of 5-aryl-3-[2-(piperidin-1-yl)ethyl]-1,2,4-oxadiazoles upon exposure to water and HCl
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DOI: 10.1007/s10593-018-2321-z
Abstract: Сhemical stability of 3-(2-aminoethyl)-5-substituted 1,2,4-oxadiazoles was studied with respect to Boulton–Katritzky rearrangement, which is known to produce planar pyrazolines and pyrazoles upon heating in DMF at 150°C or without solvent at 240°C. The reactivity of… read more here.
Keywords: hcl; katritzky rearrangement; boulton katritzky; aryl piperidin ... See more keywords
Synthesis of polysubstituted phenyl acetates via FeCl3-mediated domino reaction of 2-(aryl(piperidin-1-yl)methyl)phenols and 1,3-diketones
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DOI: 10.1016/j.tet.2017.10.045
Abstract: Abstract A one-pot domino reaction involving Lewis acid-mediated nucleophilic-substitution/intramolecular-cyclization/reverse Claisen condensation of 2-(aryl(piperidin-1-yl)methyl)phenols and 1,3-diketones has been developed for the synthesis of 2-(3-oxo-1-phenylbutyl)phenyl acetates in good to excellent yields (77%–95%). The construction of the products… read more here.
Keywords: methyl phenols; domino reaction; domino; aryl piperidin ... See more keywords