Enantioselective Desymmetrization of 2-Aryl-1,3-propanediols by Direct O-Alkylation with a Rationally Designed Chiral Hemiboronic Acid Catalyst That Mitigates Substrate Conformational Poisoning.
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DOI: 10.1021/jacs.1c00759
Abstract: Enantioselective desymmetrization by direct monofunctionalization of prochiral diols is a powerful strategy to prepare valuable synthetic intermediates in high optical purity. Boron acids can activate diols toward nucleophilic additions; however, the design of stable chiral… read more here.
Keywords: enantioselective desymmetrization; desymmetrization aryl; aryl propanediols; catalyst ... See more keywords