Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities.
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DOI: 10.1016/j.ejmech.2020.113117
Abstract: Microtubules play a vital role in cell mitosis. Drugs targeting taxol or vinca binding site of tubulin have been proved an effective way to against cancer. However, drug resistance and cancer recurrence are inevitable, there… read more here.
Keywords: aryl sulfonamido; novel aryl; pyridines hoans; compound hoan32 ... See more keywords