A facile greener synthesis, antimicrobial evaluation and molecular modelling of new 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-one derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-018-03711-1
Abstract: The synthesis of 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-ones was performed by cyclization of 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine with 2-aroylbenzoic acids in ethanol containing a catalytic amount of concentrated sulfuric acid under solid state conditions. All these synthesized compounds (8a–h) were screened for… read more here.
Keywords: phenyl naphthyridin; aryl trifluoromethyl; trifluoromethyl; trifluoromethyl phenyl ... See more keywords
Synthesis of trifluoromethyl-group-containing cyclopentadienones by the palladium-catalyzed [2 + 2 + 1] cycloaddition of aryl- and trifluoromethyl-group substituted internal alkynes and carbon monoxide
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.01.036
Abstract: Abstract We investigated the palladium-catalyzed [2 + 2 + 1] cycloaddition of aryl- and trifluoromethyl-group-substituted internal alkynes and carbon monoxide, and revealed that the PdBr2 effectively catalyzed the intended reaction. The PdBr2-catalyzed reaction smoothly proceeded and provided aryl- and… read more here.
Keywords: aryl trifluoromethyl; palladium catalyzed; trifluoromethyl group; group ... See more keywords
Practical and efficient synthesis of aryl trifluoromethyl sulfones from arylsulfonyl chlorides with Umemoto’s reagent II
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DOI: 10.1016/j.tetlet.2019.151465
Abstract: Abstract A practical and efficient method for the synthesis of aryl trifluoromethyl sulfones has been developed by a tandem reaction of arylsulfonyl chlorides with Umemoto’s reagent II. The advantageous features of this method are simple… read more here.
Keywords: trifluoromethyl sulfones; aryl trifluoromethyl; practical efficient; arylsulfonyl chlorides ... See more keywords
Mechanochemical Conversion of Aromatic Amines to Aryl Trifluoromethyl Ethers
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DOI: 10.1021/jacs.2c02611
Abstract: Increased interest in the trifluoromethoxy group in organic synthesis and medicinal chemistry has induced a demand for new, selective, general, and faster methods applicable to natural products and highly functionalized compounds at a later stage… read more here.
Keywords: mechanochemical conversion; aromatic amines; trifluoromethyl ethers; aryl trifluoromethyl ... See more keywords