Hunig's base catalyzed synthesis of new 1-(2,3-dihydro-1H-inden-1-yl)-3-aryl urea/thiourea derivatives as potent antioxidants and 2HCK enzyme growth inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103558
Abstract: A series of 1-(2,3-dihydro-1H-indan-1-yl)-3-aryl urea/thiourea derivatives (4a-j) have been synthesized from the reaction of 2,3-dihydro-1H-inden-1-amine (2) with various aryl isocyanates/isothiocyanates (3a-j) by using N,N-DIPEA base (Hunig's base) catalyst in THF at reflux conditions. All of… read more here.
Keywords: dihydro inden; aryl urea; base; urea thiourea ... See more keywords
Aryl‐urea fatty acids that activate the p38 MAP kinase and down‐regulate multiple cyclins decrease the viability of MDA‐MB‐231 breast cancer cells☆
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.12.015
Abstract: ABSTRACT We recently developed a novel aryl‐urea fatty acid (CTU; 16({[4‐chloro‐3‐(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoic acid) that impaired the viability of MDA‐MB‐231 breast cancer cells in vitro and in mouse xenograft models in vivo. At present there is a… read more here.
Keywords: mda 231; urea fatty; aryl urea; breast cancer ... See more keywords
Biochemical and microbiological evaluation of N-aryl urea derivatives against mycobacteria and mycobacterial hydrolases.
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DOI: 10.1039/c9md00122k
Abstract: A focused library of 24 N-aryl urea derivatives was prepared and evaluated against serine esterases of Mycobacterium tuberculosis (Mtb) Rv3802c and Mtb Ag85C. The members of the library were evaluated for both selectivity and mode… read more here.
Keywords: biochemical microbiological; aryl urea; urea derivatives; mtb ... See more keywords
Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents
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DOI: 10.3390/molecules27113616
Abstract: Natural cytokinines are a promising group of cytoprotective and anti-tumor agents. In this research, we synthesized a set of aryl carbamate, pyridyl urea, and aryl urea cytokinine analogs with alkyl and chlorine substitutions and tested… read more here.
Keywords: aryl; aryl carbamates; activity; aryl urea ... See more keywords
The Design and Synthesis of a New Series of 1,2,3-Triazole-Cored Structures Tethering Aryl Urea and Their Highly Selective Cytotoxicity toward HepG2
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DOI: 10.3390/ph15050504
Abstract: Target cancer drug therapy is an alternative treatment for advanced hepatocellular carcinoma (HCC) patients. However, the treatment using approved targeted drugs has encountered a number of limitations, including the poor pharmacological properties of drugs, therapy… read more here.
Keywords: cored structures; triazole cored; series triazole; new series ... See more keywords