Highly Regioselective C–H Alkylation of Alkenes Through an Aryl to Vinyl 1,4-Palladium Migration/C–C Cleavage Cascade
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DOI: 10.1021/acscatal.9b04161
Abstract: Palladium-catalyzed C−H alkylation of gem-disubstituted ethylenes has been efficiently achieved with cyclobutanols as the coupling partners through an aryl to vinyl 1,4-palladium migration/ring-opening C–C cleavage cascade, giving trisubstituted alkenes in high yields. The protocol features… read more here.
Keywords: cleavage; palladium migration; aryl vinyl; palladium ... See more keywords
Asymmetric synthesis of aryl/vinyl alkyl carbinol esters via Ni-catalyzed reductive arylation/vinylation of 1-chloro-1-alkanol esters
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc02806a
Abstract: We report herein an asymmetric Ni-catalyzed cross-electrophile coupling approach to prepare enantioenriched aryl/vinyl alkyl carbinol esters through arylation/vinylation of easily accessible racemic 1-chloro-1-alkanol esters with aryl/vinyl electrophiles. The method features a broad substrate scope as… read more here.
Keywords: alkyl carbinol; arylation vinylation; aryl vinyl; carbinol esters ... See more keywords