Copper-Mediated Decarboxylative Coupling between Arylacetic Acids and 1,3-Dicarbonyl Compounds.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02897
Abstract: A copper-mediated decarboxylative coupling reaction between arylacetic acids and 1,3-dicarbonyl compounds was described. Significantly, methanocycloocta[b]indoles were also obtained by sequential intramolecular dehydrocyclization process in some cases. This protocol featured a broad substrate scope, simple operations,… read more here.
Keywords: acids dicarbonyl; mediated decarboxylative; copper mediated; dicarbonyl compounds ... See more keywords
Nickel-Catalyzed Oxidative Carbonylation of Alkylarenes to Arylacetic Acids.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03121
Abstract: A catalytic system combined with NiBr2 and diphenylphosphine oxide that enabled direct access to the valuable arylacetic acids from inexpensive alkylarenes and H2O via oxidative carbonylation was developed. Alkylarenes with primary and secondary benzylic C-H… read more here.
Keywords: carbonylation alkylarenes; catalyzed oxidative; nickel catalyzed; oxidative carbonylation ... See more keywords
Copper-Catalyzed One-Pot Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from Arylacetic Acids and Hydrazides via Dual Oxidation
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DOI: 10.1021/acsomega.2c01586
Abstract: A simple and efficient protocol has been developed to access symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles from arylacetic acids and hydrazides via copper-catalyzed dual oxidation under an oxygen atmosphere. Oxidative decarboxylation of arylacetic acids and oxidative… read more here.
Keywords: acids hydrazides; oxadiazoles arylacetic; dual oxidation; disubstituted oxadiazoles ... See more keywords
Functionalization of arylacetic acids via directing-group-assisted remote meta-C-H activation.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01050c
Abstract: Herein, we report the first microwave-assisted remote-C-H functionalization aided by a simple nitrile directing template. Notably, the present protocol showed a broad substrate scope VIA enabling meta-C-H arylation, acetoxylation, and cyanation. Significantly, the microwave-accelerated meta-C-H… read more here.
Keywords: assisted remote; functionalization; acids via; via directing ... See more keywords
Iron-Promoted Decarboxylation of Arylacetic Acids for the Synthesis of Aromatic Nitriles with Sodium Nitrite as the Nitrogen Source
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DOI: 10.1055/s-0040-1707300
Abstract: A new and effective method was developed for the synthesis of aromatic nitriles from arylacetic acids by using NaNO2 as the nitrogen source and Fe(OTf)3 as the promoter at 50 °C. A series of arylacetic… read more here.
Keywords: aromatic nitriles; synthesis aromatic; nitrogen source; arylacetic acids ... See more keywords