A Mechanistic Insight into the Ligand-Controlled Asymmetric Arylation of Aliphatic α-Amino Anion Equivalents: Origin of Regio- and Enantioselectivities.
Sign Up to like & getrecommendations! Published in 2017 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.7b00739
Abstract: The reaction mechanism and the origins of regio- and enantioselectivities for Pd-catalyzed asymmetric arylation of aliphatic α-amino anion equivalents were investigated computationally. The results indicate that the reaction proceeds via mainly six sequential steps: deprotonation… read more here.
Keywords: amino; arylation aliphatic; asymmetric arylation; regio enantioselectivities ... See more keywords
Palladium-Catalyzed β-C-H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00366
Abstract: This paper describes a new amino-amide-based transient directing group (TDG). The TDG can exhibit better performance in the Pd-catalyzed arylation of aliphatic aldehydes and ketones. This reaction showed good substrate compatibility and regioselectivity. The results… read more here.
Keywords: aliphatic aldehydes; directing group; arylation aliphatic; amino amide ... See more keywords
Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids
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DOI: 10.1038/ncomms14904
Abstract: α-amino acids bearing aromatic side chains are important synthetic units in the synthesis of peptides and natural products. Although various β-C-H arylation methodologies for amino acid derivatives involving the assistance of directing groups have been… read more here.
Keywords: arylation aliphatic; aliphatic acids; arylation; ligand enabled ... See more keywords