Reductive 1,2-Arylation of Isatins.
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DOI: 10.1021/acs.orglett.2c03042
Abstract: We report an intermolecular Ni-catalyzed reductive coupling of aryl iodides and isatins to form 3-hydroxyoxindoles. In contrast to common metal-mediated methods, sec-butanol is used as a mild stoichiometric reductant resulting in benign waste products. This… read more here.
Keywords: reductive arylation; arylation isatins;