Copper-catalyzed synthesis of trifluoromethylated bis(indolyl)arylmethanes from 2-arylindoles and 2,2,2-trifluoroacetohydrazide
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DOI: 10.1039/c9qo01131e
Abstract: One-pot synthesis of trifluoromethylated bis(indolyl)arylmethanes through copper-catalyzed reaction of 2-arylindoles with 2,2,2-trifluoroacetohydrazide is described. This viable transformation provides a variety of 3,3′-bis(indolyl)methanes with a CF3-containing tertiary carbon center in moderate to good yields. Preliminary mechanistic… read more here.
Keywords: bis indolyl; indolyl arylmethanes; trifluoromethylated bis; arylindoles trifluoroacetohydrazide ... See more keywords