An Organocatalyzed Efficient One‐pot Synthesis, Biological Evaluation, and Molecular Docking Studies of 4,4′‐(Arylmethylene)bis‐(3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐ols)
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DOI: 10.1002/jhet.2681
Abstract: The synthesis of 4,4′-(arylmethylene)bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol) derivatives catalyzed by ʟ-proline is a simple, versatile, and efficient method. In vitro antioxidant, anti-inflammatory, and antimicrobial activities of compounds were studied. Furthermore, to rationalize the observed anti-inflammatory activity data, molecular… read more here.
Keywords: bis methyl; synthesis; arylmethylene bis; methyl phenyl ... See more keywords
Effective preparation of 5,5’-(arylmethylene)bis(4-hydroxythiazole-2(3H)-one) in an aqueous fluoroalcohol solvent system under ultrasound irradiation at room temperature
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2017.01.015
Abstract: Abstract A green and convenient approach for the synthesis of a series of 5,5'-(arylmethylene)bis(4-hydroxythiazole-2(3H)-one) by the reaction of aryl aldehydes, monochloroacetic acid and ammonium thiocyanate in water/trifluoroethanol(TFE) (1:1) under ultrasound irradiation at room temperature is… read more here.
Keywords: irradiation room; ultrasound irradiation; hydroxythiazole one; bis hydroxythiazole ... See more keywords
One-pot efficient pseudo-five-components synthesis of 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) at room temperature assisted by K2CO3
Sign Up to like & getrecommendations! Published in 2017 at "Synthetic Communications"
DOI: 10.1080/00397911.2017.1298134
Abstract: ABSTRACT A convenient approach for the synthesis of 4,4′-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) by an efficient one-pot reaction of aromatic aldehydes, phenylhydrazine, and ethyl acetoacetate by using substoichiometric amount of K2CO3 in acetonitrile solvent at room temperature is described.… read more here.
Keywords: arylmethylene bis; synthesis; synthesis arylmethylene; one pot ... See more keywords
Efficient and Green Synthesis of 2,2′-(Arylmethylene)Bis-4-Pyrones in an Ionic Liquid [bmim+][BF4–]
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DOI: 10.3184/174751917x14837116219618
Abstract: A series of sixteen 2,2′-(arylmethylene)bis(3-hydroxy-6-methyl-4H-pyran-4-ones) have been prepared in high yield via an ammonium acetate-catalysed three-component reaction of an aromatic aldehyde (1 equiv.) and allomaltol (2 equiv.) in an ionic liquid [bmim+][BF4–]. The reaction work-up… read more here.
Keywords: ionic liquid; liquid; liquid bmim; arylmethylene bis ... See more keywords
Evaluation of the Anti-Leishmania mexicana and -Trypanosoma brucei Activity and Mode of Action of 4,4′-(Arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)
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DOI: 10.3390/biomedicines10081913
Abstract: Trypanosomiasis and leishmaniasis are neglected infections caused by trypanosomatid parasites. The first-line treatments have many adverse effects, high costs, and are prone to resistance development, hence the necessity for new chemotherapeutic options. In line with… read more here.
Keywords: brucei; trypanosoma brucei; leishmania mexicana; mexicana trypanosoma ... See more keywords