A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug targets"
DOI: 10.2174/1389450123666220117104038
Abstract: Neurological disorders are disease conditions related to the neurons and central nervous system (CNS). Any kind of structural, electrical, biochemical and functional abnormalities in neurons can lead to various types of disorders like Alzheimer's disease… read more here.
Keywords: derivatives potential; neurological disorders; different neurological; arylpiperazine derivatives ... See more keywords
Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents.
Sign Up to like & getrecommendations! Published in 2017 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520616666160926120904
Abstract: BACKGROUND Protease activated receptor-1 (PAR1) is a G-coupled receptor activated by α-thrombin and other proteases. Several reports have demonstrated the PAR1 involvement in tumorigenesis and tumor progression. In order to investigate on potential use of… read more here.
Keywords: par1; arylpiperazine derivatives; antiproliferative agents; protease activated ... See more keywords
Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.947065
Abstract: Prostate cancer is one of the malignant tumors and the second most common malignant tumor in men. Clinically used androgen receptor (AR)–targeted drugs can antagonize androgen and inhibit tumor growth, but these drugs can cause… read more here.
Keywords: molecular docking; arylpiperazine derivatives; novel arylpiperazine; bioactivity molecular ... See more keywords