Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin.
Sign Up to like & getrecommendations! Published in 2021 at "Redox biology"
DOI: 10.1016/j.redox.2021.102174
Abstract: Asbestos-associated diseases remain a social burden worldwide. Our previous studies identified asbestos-induced iron-rich milieu for mesothelial cells with ceaseless macrophage ferroptosis. However, molecular mechanisms how this mutagenic milieu influences mesothelial cells have not been elucidated… read more here.
Keywords: extracellular vesicles; asbestos induced; ferroptosis dependent; mesothelial cells ... See more keywords
Asbestos‐induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species
Sign Up to like & getrecommendations! Published in 2021 at "Pathology International"
DOI: 10.1111/pin.13196
Abstract: Asbestos fibers have been used as an industrial and construction material worldwide due to their high durability and low production cost. Commercial usage of asbestos is currently prohibited in Japan; however, the risk of asbestos‐induced… read more here.
Keywords: oxygen species; asbestos induced; iron; reactive oxygen ... See more keywords
The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/7395238
Abstract: Background The interaction of asbestos with macrophages drives two key processes that are linked to malignancy: (1) the generation of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and (2) the activation of an inflammation cascade… read more here.
Keywords: asbestos induced; activation; induced nlrp3; nlrp3 inflammasome ... See more keywords
Commentary on “Mechanisms of asbestos-induced carcinogenesis” published in 2009
Sign Up to like & getrecommendations! Published in 2023 at "Nagoya Journal of Medical Science"
DOI: 10.18999/nagjms.85.1.13
Abstract: . Respiratory exposure to asbestos fibers has been associated with diffuse malignant mesothelioma (DMM) in humans. Despite advancements in the molecular analyses of human DMM and the development of animal models, the carcinogenic mechanisms of… read more here.
Keywords: asbestos induced; asbestos; commentary mechanisms; asbestos fibers ... See more keywords
Inflammatory Alteration of Human T Cells Exposed Continuously to Asbestos
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19020504
Abstract: Asbestos is a known carcinogen and exposure can lead to lung cancer and malignant mesothelioma. To examine the effects of asbestos fibers on human immune cells, the human T cell leukemia/lymphoma virus (HTLV)-1 immortalized human… read more here.
Keywords: asbestos fibers; asbestos induced; inflammation; chronic inflammation ... See more keywords
Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231710085
Abstract: Although alveolar macrophages play a critical role in malignant transformation of mesothelial cells following asbestos exposure, inflammatory and oxidative processes continue to occur in the mesothelial cells lining the pleura that may contribute to the… read more here.
Keywords: cell; asbestos induced; damage; asbestos ... See more keywords