Irinotecan‐induced bile acid malabsorption is associated with down‐regulation of ileal Asbt (Slc10a2) in mice
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.03.012
Abstract: &NA; Irinotecan, (CPT‐11), an antitumor agent primarily used for the treatment of solid tumors, has often compromised clinical application due to the inducement of severe delay‐onset diarrhea. Bile acid malabsorption (BAM) is widely accepted as… read more here.
Keywords: cpt; treatment; asbt; acid malabsorption ... See more keywords
Modulatory Effect of Theaflavins on Apical Sodium-Dependent Bile Acid Transporter (ASBT) Activity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c03483
Abstract: Inhibiting apical sodium-dependent bile acid transporter (ASBT) has been identified as a potential strategy to reduce plasma cholesterol levels. Thus, in this study, we aimed to identify polyphenols that inhibited ASBT activity and to elucidate… read more here.
Keywords: acid transporter; apical sodium; asbt; bile acid ... See more keywords
A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multi-organ activity and shows translational relevance to humans.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000376
Abstract: BACKGROUND AIMS Cholestasis is characterized by intrahepatic accumulation of bile constituents, including bile acids (BAs), which promote liver damage. The apical sodium-dependent BA transporter (ASBT) plays an important role in BA reabsorption and signaling in… read more here.
Keywords: cholestasis; asbt; activity; asbt inhibitor ... See more keywords