A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multi-organ activity and shows translational relevance to humans.
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DOI: 10.1097/hep.0000000000000376
Abstract: BACKGROUND AIMS Cholestasis is characterized by intrahepatic accumulation of bile constituents, including bile acids (BAs), which promote liver damage. The apical sodium-dependent BA transporter (ASBT) plays an important role in BA reabsorption and signaling in… read more here.
Keywords: cholestasis; asbt; activity; asbt inhibitor ... See more keywords