Detection of ASC Speck Formation by Flow Cytometry and Chemical Cross-linking.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7519-8_10
Abstract: Assembly of a relatively large protein aggregate or "speck" formed by the adaptor protein ASC is a common downstream step in the activation of most inflammasomes. This unique feature of ASC allows its visualization by… read more here.
Keywords: asc speck; formation flow; speck formation; speck ... See more keywords
Inflammasome activation in neutrophils of patients with severe COVID-19
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DOI: 10.1182/bloodadvances.2021005949
Abstract: Neutrophils with intact multilobulated nuclei show ASC speck formation and high histone H3 citrullination in patients with severe COVID-19. In murine neutrophils, ASC speck forms transiently at the microtubule organizing center, before nuclear rounding, early… read more here.
Keywords: activation; microscopy; asc speck; formation ... See more keywords
Crosstalk Between the NLRP3 Inflammasome/ASC Speck and Amyloid Protein Aggregates Drives Disease Progression in Alzheimer’s and Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.805169
Abstract: Two key pathological hallmarks of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), are the accumulation of misfolded protein aggregates and the chronic progressive neuroinflammation that they trigger. Numerous original research and reviews… read more here.
Keywords: disease; asc speck; protein aggregates;