Particulate matter aggravates Alzheimer's disease by activating the NLRP3 inflammasome to release ASC specks
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Science: Nano"
DOI: 10.1039/d1en00361e
Abstract: PM2.5 activated the NLRP3 inflammasome to release ASC specks and interact with the Aβ monomer to induce Aβ aggregation, further inducing AD. read more here.
Keywords: nlrp3 inflammasome; asc specks; inflammasome release; release asc ... See more keywords
Alcohol-induced extracellular asc specks perpetuate liver inflammation and damage in alcoholic hepatitis even after alcohol cessation.
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DOI: 10.1097/hep.0000000000000298
Abstract: BACKGROUND AIMS Prolonged systemic inflammation contributes to poor clinical outcomes in severe alcohol-associated hepatitis (AH) even after cessation of alcohol use. However, mechanisms leading to this persistent inflammation remain to be understood. APPROACH RESULTS We… read more here.
Keywords: alcohol; liver inflammation; alcohol induced; asc specks ... See more keywords
Unknown/enigmatic functions of extracellular ASC
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DOI: 10.1111/imm.13375
Abstract: Apoptosis‐associated speck‐like protein containing a caspase recruit domain (ASC), encoded by PYCARD gene, is a 22 kDa small molecule, which aggregates into ASC specks during inflammasome activation. ASC protein is an adaptor protein present in… read more here.
Keywords: enigmatic functions; asc; extracellular asc; asc specks ... See more keywords
The intra‐ and extracellular functions of ASC specks
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DOI: 10.1111/imr.12611
Abstract: Inflammasomes are the central signaling hubs of the inflammatory response. They process cytosolic evidence of infection, cell damage, or metabolic disturbances, and elicit a pro‐inflammatory response mediated by members of the interleukin‐1 family of cytokines… read more here.
Keywords: extracellular functions; response; asc; asc specks ... See more keywords
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo
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DOI: 10.15252/emmm.202115415
Abstract: Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines. Caspase‐1 also drives pyroptosis, a… read more here.
Keywords: inflammation; asc specks; post pyroptotic; nanobodies dismantle ... See more keywords