Improved Synthesis for Modular Ascarosides Uncovers Biological Activity.
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DOI: 10.1021/acs.orglett.7b01009
Abstract: A versatile synthesis of modular ascarosides, a family of signaling molecules from Caenorhabditis elegans and other nematodes, via hydrogenolysis of a cyclic sulfate derived from methyl-α-l-rhamnopyranoside is reported. The route enables selective introduction of different… read more here.
Keywords: ascarosides uncovers; modular ascarosides; synthesis modular; improved synthesis ... See more keywords