Improving outcomes for the treatment of Anal Squamous Cell Carcinoma and Anal Intraepithelial Neoplasia
Sign Up to like & getrecommendations! Published in 2019 at "Techniques in Coloproctology"
DOI: 10.1007/s10151-019-02121-8
Abstract: Anal Squamous Cell Carcinoma (ASCC) is an uncommon cancer, with an incidence rate between 1 and 2 per 100,000 per year. However, its incidence is significantly increasing in established market economies; where incidence rates in… read more here.
Keywords: ascc; incidence; treatment; intraepithelial neoplasia ... See more keywords
Anal squamous cell carcinoma - State of the art management and future perspectives.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2018.02.001
Abstract: Anal squamous cell carcinoma (ASCC) is associated with infection with high-risk strains of human papilloma virus (HPV) in 70-90% of cases and a rise in incidence has been observed in the last decades. Definitive chemoradiotherapy… read more here.
Keywords: ascc; anal squamous; cell carcinoma; squamous cell ... See more keywords
A clinical and molecular portrait of non-metastatic anal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101084
Abstract: Highlights • High-risk HPV infection is less frequently detected in HIV-positive non-metastatic ASCC compared with HIV-negative cases.• Mutational profile identified in the non-metastatic ASCC cohort revealed expected similarities with metastatic ASCC.• High PD-L1 expression levels… read more here.
Keywords: ascc; metastatic ascc; clinical molecular; portrait non ... See more keywords
Targeting phosphorylation of STAT3 delays tumor growth in HPV-negative anal squamous cell carcinoma mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06643-9
Abstract: Although conventional chemoradiotherapy is effective for most anal squamous cell carcinoma (ASCC) patients, HPV-negative ASCC patients respond poorly to this treatment and new therapeutic approach is required. Our group has previously established an HPV-negative ASCC… read more here.
Keywords: ascc; model; mouse model; cell ... See more keywords